CAS 402-49-3

4-(Trifluoromethyl)benzyl bromide

Description:

4-(Trifluoromethyl)benzyl bromide is an organic compound characterized by the presence of a bromobenzyl group with a trifluoromethyl substituent at the para position. Its molecular formula is C9H7BrF3, indicating the presence of carbon, hydrogen, bromine, and fluorine atoms. This compound typically appears as a colorless to pale yellow liquid and is known for its reactivity due to the presence of the bromine atom, which can participate in nucleophilic substitution reactions. The trifluoromethyl group contributes to the compound's unique electronic properties, enhancing its lipophilicity and potentially influencing its biological activity. 4-(Trifluoromethyl)benzyl bromide is often utilized in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals, due to its ability to serve as an electrophilic reagent. Safety precautions should be taken when handling this compound, as it may pose health risks through inhalation or skin contact. Proper storage and disposal methods are essential to mitigate environmental impact and ensure safety in laboratory settings.

Formula: C₈H₆BrF₃

InChI: InChI=1S/C8H6BrF3/c9-5-6-1-3-7(4-2-6)8(10,11)12/h1-4H,5H2

InChI key: InChIKey=IKSNDOVDVVPSMA-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=CC=C(CBr)C=C1

Synonyms:

• 1-Trifluoromethyl-4-(bromomethyl)benzene
• 4-(Trifluoromethyl)Benzyl Bromide
• 4-Bromomethylbenzotrifluoride
• 4-Trifluoromethylbenzyl Bromide
• Benzene, 1-(bromomethyl)-4-(trifluoromethyl)-
• p-(Trifluoromethyl)benzyl bromide
• p-Xylene, α′-bromo-α,α,α-trifluoro-
• α′-Bromo-α,α,α-trifluoro-p-xylene
• 1-(Bromomethyl)-4-(trifluoromethyl)benzene

4-(Trifluoromethyl)benzyl Bromide

CAS: 402-49-3

Formula: C₈H₆BrF₃

Purity: >98.0%(GC)

Color and Shape: White or Colorless to Light yellow powder to lump to clear liquid

Molecular weight: 239.04

Ref: 3B-T1313

4-(Trifluoromethyl)benzyl bromide, 98%

CAS: 402-49-3

4-(Trifluoromethyl)benzyl bromide can be used to produce p-trifluoromethylbenzyl phenyl sulfide. It is used in medicine. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The

Formula: C₈H₆BrF₃

Purity: 98%

Color and Shape: Crystals or powder or crystalline powder or fused solid, White to cream

Molecular weight: 239.04

Ref: 02-A16895

4-(Trifluoromethyl)benzyl bromide

CAS: 402-49-3

Formula: C₈H₆BrF₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 239.0324

Ref: IN-DA0033U8

4-(Trifluoromethyl)benzyl bromide

CAS: 402-49-3

4-(Trifluoromethyl)benzyl bromide

Formula: C₈H₆BrF₃

Purity: 98%

Color and Shape: white to off white fused solid

Molecular weight: 239.03g/mol

Ref: 54-PC7633

4-(Trifluoromethyl)benzyl bromide

CAS: 402-49-3

Formula: C₈H₆BrF₃

Purity: 98.0%

Color and Shape: Low Melting Solid

Molecular weight: 239.035

Ref: 10-F007607

4-(Trifluoromethyl)benzyl Bromide

Controlled Product

CAS: 402-49-3

Applications 4-(Trifluoromethyl)benzyl Bromide is a useful building block. It is used in the synthesis of 1-(Substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles with antiviral activities.It is also used to prepare 2-[(4-diarylmethoxy)phenyl]benzimidazoles as potent inhibitors of hepatitis C virus NS5B polymerase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Porcari, A., et al.: J. Med. Chem., 41, 1252 (1998); Ishida, T., et al.: Bioorg. Med. Chem. Lett., 16, 1859 (2006)

Formula: C₈H₆BrF₃

Color and Shape: Neat

Molecular weight: 239.03

Ref: TR-T790585

4-(Trifluoromethyl)benzyl bromide

CAS: 402-49-3

4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond.

Formula: C₈H₆BrF₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 239.03 g/mol

Ref: 3D-FT34370