CAS 4025-67-6

Benzenesulfonyl chloride, 4-hydroxy-

Description:

4-Hydroxybenzenesulfonyl chloride, also known as para-hydroxybenzenesulfonyl chloride, is an aromatic sulfonyl chloride characterized by the presence of a sulfonyl group (–SO2Cl) attached to a benzene ring that also bears a hydroxyl group (–OH) in the para position relative to the sulfonyl group. This compound is typically a white to light yellow solid that is soluble in organic solvents such as dichloromethane and ether but is generally insoluble in water due to its hydrophobic aromatic structure. It is reactive, particularly with nucleophiles, making it useful in organic synthesis, especially for the preparation of sulfonamide derivatives and other functionalized aromatic compounds. The presence of the hydroxyl group can influence its reactivity and solubility properties. As with many sulfonyl chlorides, it can release hydrogen chloride upon hydrolysis, necessitating careful handling and storage under inert conditions to prevent moisture exposure. Safety precautions should be taken due to its corrosive nature and potential to cause irritation.

Formula: C₆H₅ClO₃S

Synonyms:

• 4-Hydroxy-Benzenesulfonyl Chloride
• 4-Hydroxybenzenesulfonyl chloride

4-HYDROXY-BENZENESULFONYL CHLORIDE

CAS: 4025-67-6

Formula: C₆H₅ClO₃S

Purity: 95%

Color and Shape: Solid

Molecular weight: 192.6201

Ref: IN-DA00BY6P

4-Hydroxybenzenesulfonyl chloride

CAS: 4025-67-6

4-Hydroxybenzenesulfonyl chloride

Formula: C₆H₅ClO₃S

Purity: 98%

Color and Shape: white to off-white solid

Molecular weight: 192.62g/mol

Ref: 54-OR925449

4-Hydroxybenzenesulfonyl Chloride

CAS: 4025-67-6

Formula: C₆H₅ClO₃S

Molecular weight: 192.61

Ref: 4Z-B-4450

4-Hydroxybenzenesulfonyl chloride

CAS: 4025-67-6

4-Hydroxybenzenesulfonyl chloride is a thionyl chloride derivative that reacts with pyridine in the presence of an dehydrating agent to form a polyurethane. The dehydration of 4-hydroxybenzenesulfonyl chloride is conducted by reacting it with magnesium and carboxylate in xylene, with subsequent reaction with chlorine to produce thiomorpholine. Thiomorpholine can be further reacted with thionyl chloride to produce sulfate. This compound has been shown to induce TNF-α production in mouse macrophages, which may be due to its ability to inhibit protein synthesis and induce apoptosis. 4-Hydroxybenzenesulfonyl chloride also has high yield for the synthesis of polyurethane, making it a popular choice for use in industrial applications.

Formula: C₆H₅ClO₃S

Purity: Min. 85 Area-%

Color and Shape: Powder

Molecular weight: 192.62 g/mol

Ref: 3D-FH11264

4-Hydroxybenzenesulfonyl chloride

CAS: 4025-67-6

Purity: 95%

Color and Shape: Solid

Molecular weight: 192.6100006

Ref: 10-F615745

4-Hydroxybenzenesulfonyl Chloride

Controlled Product

CAS: 4025-67-6

Stability Moisture Sensitive
Applications 4-Hydroxybenzenesulfonyl Chloride is useful for the preparation of amino acid derivatives with anticancer activity.
References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1

Formula: C₆H₅O₃SCl

Color and Shape: Neat

Molecular weight: 192.62

Ref: TR-H999963