CAS 40277-05-2

4-Hydroxycyclophosphamide

Description:

4-Hydroxycyclophosphamide is a chemical compound that belongs to the class of alkylating agents, primarily used in cancer chemotherapy. It is a derivative of cyclophosphamide, which is a prodrug that requires metabolic activation. The compound features a hydroxyl group (-OH) at the 4-position of the cyclophosphamide structure, which enhances its reactivity and therapeutic efficacy. 4-Hydroxycyclophosphamide is known for its ability to form DNA cross-links, leading to the inhibition of DNA synthesis and ultimately inducing apoptosis in rapidly dividing cancer cells. This compound is typically administered in a clinical setting for the treatment of various malignancies, including lymphomas and solid tumors. Its pharmacokinetics involve conversion to other active metabolites, and it is important to monitor for potential side effects, such as myelosuppression and bladder toxicity. The compound is also studied for its role in immunosuppressive therapies. As with many chemotherapeutic agents, careful dosing and patient management are crucial to maximize therapeutic benefits while minimizing adverse effects.

Formula: C₇H₁₅Cl₂N₂O₃P

InChI: InChI=1S/C7H15Cl2N2O3P/c8-2-4-11(5-3-9)15(13)10-7(12)1-6-14-15/h7,12H,1-6H2,(H,10,13)

InChI key: InChIKey=RANONBLIHMVXAJ-UHFFFAOYSA-N

SMILES: N(CCCl)(CCCl)P1(=O)NC(O)CCO1

Synonyms:

• 2-[Bis(2-chloroethyl)amino]-4-hydroxy-1,3,2λ5-oxazaphosphinan-2-one
• 2-[Bis(2-chloroethyl)amino]tetrahydro-4-hydroxy-2H-1,3,2-oxazaphosphorine 2-oxide
• 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroxytetrahydro-, 2-oxide
• 2H-1,3,2-oxazaphosphorin-4-ol, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
• 4-Hydroxycyclophosphamide
• Asta 6635
• NSC 196562

4-Hydroxy Cyclophosphamide

CAS: 40277-05-2

Formula: C₇H₁₅Cl₂N₂O₃P

Molecular weight: 277.09

Ref: 4Z-C-1022