CAS 402824-96-8

6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide

Description:

6-Chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide, with CAS number 402824-96-8, is a complex organic compound characterized by its multi-ring structure and the presence of sulfonamide and dioxo functional groups. This compound features a chloro substituent, which contributes to its reactivity and potential biological activity. The presence of thiadiazine rings suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The sulfonamide group is known for its antibacterial properties, indicating that this compound may exhibit similar biological activities. Its intricate structure may also influence its solubility, stability, and interaction with biological targets. Overall, this compound represents a class of heterocyclic compounds that may have significant implications in drug discovery and development, particularly in targeting specific enzymes or receptors in various therapeutic areas. Further studies would be necessary to elucidate its full chemical behavior and potential applications.

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

InChI: InChI=1/C15H16Cl2N6O8S4/c16-8-1-10-14(34(28,29)20-5-19-10)4-13(8)33(26,27)21-6-23-7-22-35(30,31)15-3-12(32(18,24)25)9(17)2-11(15)23/h1-4,19-22H,5-7H2,(H2,18,24,25)

SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)NCN1CNS(=O)(=O)c2cc(c(cc12)Cl)S(=O)(=O)N)Cl

Synonyms:

• Hydrochlorothiazide EP Impurity C (Hydrochlorothiazide Dimer)
• Hydrochlorothiazide EP impurity C/ Dimer
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode
• 6
• ,2,4-benzothiadiazin-7-yl)sulfonylamino]methyl]-1,1-dioxo-2,3-dihydro-1λ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
• Hydrochlorothiazide Impurity C
• 6-chloro-4-((6-chloro-1,1-dioxido-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamido)methyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
• Hydrochlorothiazide IMpurity-C(EP)
• Hydrochlorothiazide Dimer
• 6-chloro-4-[[(6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ
• HCTZ-CH2-HCTZ
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide\nHydrochlorothiazide Impurity C:
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamid
• N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, N-[[7-(aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxido-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-, 1,1-dioxide
• 6-Chloro-N-[(6-chloro-7-sulfamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• ,2,4-benzothiadiazine-7-sulfonamide

Hydrochlorothiazide Dimer (6-Chloro-4-({[(6-chloro-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl)sulfonyl]amino}methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide)

CAS: 402824-96-8

Sulfonamides, nesoi

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Color and Shape: White Solid

Molecular weight: 605.92895

Ref: 45-1A15670

N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxode

CAS: 402824-96-8

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 607.4889

Ref: IN-DA00C9HM

Hydrochlorothiazide EP Impurity C

CAS: 402824-96-8

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Color and Shape: White To Off-White Solid

Molecular weight: 607.47

Ref: 4Z-H-054

HCTZ-CH2-HCTZ

CAS: 402824-96-8

HCTZ-CH2-HCTZ

Purity: 98%

Ref: 54-OR1037135

Hydrochlorothiazide Impurity C

CAS: 402824-96-8

Impurity C in hydrochlorothiazide, a thiazide diuretic blocking NaCl cotransporter in kidneys.

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Color and Shape: Solid

Molecular weight: 607.49

Ref: TM-T35728

6-Chloro-N-[(6-chloro-7-sulphamoyl-2,3-dihydro-4H-1,2,4-benzothiadiazin-4-yl 1,1-Dioxide)methyl]-3,4-dihydro-2H-1,2,4-benzothia-diazine-7-sulphonamide 1,1-Dioxide

CAS: 402824-96-8

Color and Shape: Neat

Ref: 86-MM0011.04

Hydrochlorothiazide Dimer

CAS: 402824-96-8

Impurity Hydrochlorothiazide EP Impurity C
Applications N-[[7-(Aminosulfonyl)-6-chloro-2,3-dihydro-1,1-dioxo-4H-1,2,4-benzothiadiazin-4-yl]methyl]-6-chloro-3,4-dihydro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide (Hydrochlorothiazide EP Impurity C) is an impurity in bulk Hydrochlorothiazide. Dimer Impurity C.
References Daniels, S.L., et al.: J. Pharm. Sci., 70, 211 (1981), Fang, X., et al.: Pharm. Res., 14, 691 (1997),

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Color and Shape: Off-White

Molecular weight: 607.49

Ref: TR-A629375

Hydrochlorothiazide EP impurity C

CAS: 402824-96-8

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Molecular weight: 607.47

Ref: ST-EA-CP-H3003

Hydrochlorothiazide impurity C

CAS: 402824-96-8

Hydrochlorothiazide is a sulfonamide that inhibits the activity of the enzyme, angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to the potent vasoconstrictor, angiotensin II. It also has antihypertensive effects by blocking the production of aldosterone, which causes sodium retention and leads to high blood pressure. It is a byproduct in reactions with substances such as valsartan. Hydrochlorothiazide may react chemically with other medicines such as ampicillin and cefaclor.

Formula: C₁₅H₁₆Cl₂N₆O₈S₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 607.49 g/mol

Ref: 3D-IA17850