CAS 403-17-8

4-Chloro-3-fluorobenzoic acid

Description:

4-Chloro-3-fluorobenzoic acid is an aromatic carboxylic acid characterized by the presence of both chlorine and fluorine substituents on the benzene ring. Specifically, the chlorine atom is located at the para position (4-position) and the fluorine atom at the meta position (3-position) relative to the carboxylic acid group (-COOH). This compound typically appears as a white to off-white solid and is known for its moderate solubility in polar solvents such as water and alcohols, while being less soluble in non-polar solvents. It exhibits acidic properties due to the carboxylic acid functional group, allowing it to donate protons in solution. The presence of electronegative halogens like chlorine and fluorine can influence the compound's reactivity, stability, and interaction with other chemical species. 4-Chloro-3-fluorobenzoic acid is often utilized in organic synthesis and may serve as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Safety precautions should be observed when handling this compound, as it may pose health risks if ingested or inhaled.

Formula: C₇H₄ClFO₂

InChI: InChI=1S/C7H4ClFO2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11)

InChI key: InChIKey=QPIBHIXKUQKNFP-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=CC(F)=C(Cl)C=C1

Synonyms:

• 3-Fluoro-4-chlorobenzoic acid
• Benzoic acid, 4-chloro-3-fluoro-
• 4-Chloro-3-fluorobenzoic acid

4-Chloro-3-fluorobenzoic Acid

CAS: 403-17-8

Formula: C₇H₄ClFO₂

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 174.56

Ref: 3B-C2891

4-Chloro-3-Fluorobenzoic Acid

CAS: 403-17-8

Formula: C₇H₄ClFO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 174.5569

Ref: IN-DA003L4O

4-Chloro-3-fluorobenzoic acid

CAS: 403-17-8

4-Chloro-3-fluorobenzoic acid

Formula: C₇H₄ClFO₂

Purity: 97%

Color and Shape: white powder

Molecular weight: 174.56g/mol

Ref: 54-PC1861H

4-Chloro-3-fluorobenzoic acid

CAS: 403-17-8

Formula: C₇H₄ClFO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 174.56

Ref: 10-F005183

4-Chloro-3-fluorobenzoic Acid

Controlled Product

CAS: 403-17-8

Applications 4-Chloro-3-fluorobenzoic Acid is a very useful precursor. It is a reagent used to synthesize 6-Hydroxy Albaconazole (H761395) which is a metabolite of Albaconazole (A511450), an antifungal agent as neuroprotectant.
References Pujol, I., et al.: J. Antimicrob. Chemother., 39, 163 (1997), Gilgado, F., et al.: J. Clin. Microbiol., 43, 4930 (2005), Raad, I., et al.: Clin. Infect. Dis., 42, 1398 (2006), Nucci, M., et al.: Clin. Microbiol. Rev., 20, 695 (2007),

Formula: C₇H₄ClFO₂

Color and Shape: Neat

Molecular weight: 174.56

Ref: TR-C427700