CAS 40321-76-4

1,2,3,7,8-Pentachlorodibenzo-p-dioxin

Description:

1,2,3,7,8-Pentachlorodibenzo-p-dioxin (PCDD) is a highly toxic chlorinated organic compound that belongs to the family of dioxins. It is characterized by its two benzene rings connected by two oxygen atoms, with five chlorine atoms substituted at specific positions on the rings. This compound is a byproduct of various industrial processes, including the production of herbicides and the combustion of organic materials. PCDD is known for its persistence in the environment, as it is resistant to degradation and can accumulate in the food chain, particularly in fatty tissues of animals. Its toxicity is primarily attributed to its ability to disrupt endocrine functions and induce various health effects, including cancer, reproductive and developmental issues, and immune system impairment. Due to its hazardous nature, 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is subject to strict regulatory controls and monitoring in many countries. Environmental exposure is a significant concern, necessitating ongoing research into its effects and remediation strategies.

Formula: C₁₂H₃Cl₅O₂

InChI: InChI=1S/C12H3Cl5O2/c13-4-1-7-8(2-5(4)14)19-12-9(18-7)3-6(15)10(16)11(12)17/h1-3H

InChI key: InChIKey=FSPZPQQWDODWAU-UHFFFAOYSA-N

SMILES: ClC1=C2C(OC=3C(O2)=CC(Cl)=C(Cl)C3)=CC(Cl)=C1Cl

Synonyms:

• 1,2,3,7,8-PeCDD
• 1,2,3,7,8-PentaCDD
• 1,2,3,7,8-Pentachlorodibenzo-p-dioxin
• 1,2,3,7,8-Pentachlorodibenzo[b,e][1,4]dioxin
• 1,2,3,7,8-Pentachlorodibenzodioxin
• 1,2,3,7,8-PnCDD
• 12378-Pcdd
• 2,3,4,7,8-Pentachlorodibenzo-p-dioxin
• 2,3,4,7,8-Pentachlorodibenzodioxin
• D 54
• Dibenzo[B,E][1,4]Dioxin, 1,2,3,7,8-Pentachloro-
• Pcdd 54

1,2,3,7,8-Pentachlorodibenzo-p-dioxin (>85%)

CAS: 40321-76-4

Formula: C₁₂H₃Cl₅O₂

Purity: >85%

Color and Shape: Neat

Molecular weight: 356.42

Ref: TR-P237953

1,2,3,7,8-Pentachlorodibenzo-p-dioxin

CAS: 40321-76-4

1,2,3,7,8-Pentachlorodibenzo-p-dioxin is a polychlorinated dibenzodioxin that binds to the aryl hydrocarbon receptor (AhR) and activates gene transcription. It has been shown to disrupt the expression of genes that are involved in fatty acid synthesis and methyl transferase reactions. This compound also inhibits the activity of human serum enzymes such as β-hydroxybutyrate dehydrogenase and β-ketoacyl reductase. The AhR is a transcription factor that regulates the expression of many genes in response to toxic substances. The AhR protein is expressed in both humans and rats with its highest levels found in fatty tissues such as adipose tissue and liver. 1,2,3,7,8-Pentachlorodibenzo-p-dioxin is metabolized by cytochrome P450 enzymes into reactive intermediates that bind with DNA or

Formula: C₁₂H₃Cl₅O₂

Purity: (%) Min. 85%

Color and Shape: Powder

Molecular weight: 356.41 g/mol

Ref: 3D-FP26796

1,2,3,7,8-Pentachlorodibenzodioxin

CAS: 40321-76-4

Formula: C₁₂H₃Cl₅O₂

Molecular weight: 356.40

Ref: 4Z-D-126007