CAS 4033-27-6
:dihydrofolic acid
Description:
Dihydrofolic acid, also known as 7,8-dihydrofolate, is a water-soluble B-vitamin derivative that plays a crucial role in the synthesis of nucleic acids and amino acids. It is a key intermediate in the metabolic pathway of folate, which is essential for cellular division and growth. Dihydrofolic acid is characterized by its structure, which includes a pteridine ring, para-aminobenzoic acid, and glutamic acid residues. This compound is typically found in the body as a result of the reduction of folic acid, facilitated by the enzyme dihydrofolate reductase. It is involved in the conversion of dietary folate into its active forms, which are necessary for DNA synthesis and repair. Dihydrofolic acid is also significant in pharmacology, as certain antibiotics, such as sulfonamides, inhibit its synthesis in bacteria, thereby exerting their antimicrobial effects. Its CAS number, 4033-27-6, is used for identification in chemical databases and regulatory contexts. Overall, dihydrofolic acid is vital for maintaining proper cellular functions and overall health.
Formula:C19H21N7O6
InChI:InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
InChI key:InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N
SMILES:O=C1C2=C(NCC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)NC(N)=N1
Synonyms:- 7,8-Dihydro-<span class="text-smallcaps">L</span>-folic acid
- 7,8-Dihydrofolic acid
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- Dihydrofolate
- Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
- L-Glutamic acid, N-(4-(((2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- (9CI)
- N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
- N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
- N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
- Nsc 165989
- L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
- Dihydrofolic acid
- Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
- N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
- 7,8-Dihydropteroyl-L-glutaMic acid
- (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
- Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid
- Folinic Acid Impurity G (7,8-Dihydrofolic Acid)
- 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2
- Levofolinate EP Impurity G
- Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)
- 2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
- N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid
- Impurity G of Calcium Levofolinate
- Folic Acid 7,8-Dihydro Impurity
- FAH2
- 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID
- DIHYDROPTEROYL-L-GLUTAMIC ACID
- Folinic Acid EP Impurity G
- See more synonyms
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Found 9 products.
7,8-Dihydrofolic Acid ((4-(((2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid)
CAS:Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFormula:C19H21N7O6Color and Shape:Brown SolidMolecular weight:443.15533(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
CAS:(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acidPurity:90%Molecular weight:443.42g/molDihydrofolic acid
CAS:Formula:C19H21N7O6Purity:≥ 90.0%Color and Shape:Off-white to beige or grey solidMolecular weight:443.41Dihydrofolic acid
CAS:<p>Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.</p>Formula:C19H21N7O6Purity:98%Color and Shape:SolidMolecular weight:443.41Dihydro Folic Acid
CAS:<p>Stability Hygroscoipic, Light and Air Sensitive<br>Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).<br>References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),<br></p>Formula:C19H21N7O6Color and Shape:Light Beige To GreyMolecular weight:443.41Dihydrofolic acid
CAS:<p>Dihydrofolic acid is an organic compound that is a derivative of folic acid. It is the reduced form of folic acid and can be used to treat certain autoimmune diseases, such as bowel disease. Dihydrofolic acid has been shown to have antimicrobial effects against infectious diseases, including tuberculosis. This compound can also be used to treat metal-chelate resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Dihydrofolic acid has been shown to have neuroprotective properties in animals models and may be a potential drug target for the treatment of Alzheimer's disease.</p>Formula:C19H21N7O6Purity:(%) Min. 90%Color and Shape:PowderMolecular weight:443.41 g/molDihydro Folic Acid-D4 (Technical Grade)
CAS:Controlled ProductFormula:C19D4H17N7O6Color and Shape:NeatMolecular weight:447.438
