CAS 40391-99-9

Pamidronic acid

Description:

Pamidronic acid is a bisphosphonate compound primarily used in the treatment of osteoporosis and conditions associated with excessive bone resorption, such as Paget's disease and certain cancers. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density. The chemical formula of pamidronic acid is C₃H₁₁N₁O₇P₂, and it features a phosphonate group that is crucial for its biological activity. This compound is typically administered intravenously due to its poor oral bioavailability. Pamidronic acid is known for its ability to reduce the risk of skeletal-related events in patients with bone metastases. In terms of physical properties, it is a white to off-white powder that is soluble in water, making it suitable for intravenous formulations. Safety and efficacy profiles have been established through clinical studies, although potential side effects may include flu-like symptoms, gastrointestinal disturbances, and, in rare cases, osteonecrosis of the jaw. Overall, pamidronic acid plays a significant role in managing bone-related disorders.

Formula: C₃H₁₁NO₇P₂

InChI: InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)

InChI key: InChIKey=WRUUGTRCQOWXEG-UHFFFAOYSA-N

SMILES: C(P(=O)(O)O)(P(=O)(O)O)(CCN)O

Synonyms:

• (3-Amino-1-Hydroxypropane-1,1-Diyl)Bis(Phosphonic Acid)
• (3-Amino-1-Hydroxypropylidene)Bisphosphonic Acid
• (3-Amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
• (3-Amino-1-hydroxypropyliden)bisphosphonsaure
• (3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate
• (α-Hydroxy-γ-aminopropylidene)diphosphonic acid
• 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid
• 3-Amino-1-hydroxypropane-1,1-diphosphonic acid
• 3-Amino-1-hydroxypropylidene-1,1-bisphosphonic acid
• 3-Amino-1-hydroxypropylidenediphosphonic acid
• ADP
• AHPrBP
• Acide (3-Amino-1-Hydroxypropylidene)Bisphosphonique
• Acido (3-Amino-1-Hidroxipropiliden)Bisfosfonico
• Amidronic acid
• Bph 5
• P,P′-(3-Amino-1-hydroxypropylidene)bis[phosphonic acid]
• Pamidronic acid
• Panolin
• Phosphonic acid, P,P'-(3-amino-1-hydroxypropylidene)bis-
• Propane-1-hydroxy-3-amino-1,1-diphosphonic acid
• Pamidronate

Disodium Pamidronate

CAS: 109552-15-0, 40391-99-9, 57248-88-1

Formula: C₃H₉NNa₂O₇P₂

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 279.03

Ref: 3B-D3921

Pamidronic acid

CAS: 40391-99-9

Formula: C₃H₁₁NO₇P₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 235.0695

Ref: IN-DA007358

Pamidronic acid

CAS: 40391-99-9

Pamidronic acid

Purity: ≥95%

Molecular weight: 235.07g/mol

Ref: 54-BUP14163

Pamidronic acid

CAS: 40391-99-9

Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells

Formula: C₃H₁₁NO₇P₂

Purity: 97.72%

Color and Shape: Solid

Molecular weight: 235.07

Ref: TM-T8400

Pamidronic Acid

Controlled Product

CAS: 40391-99-9

Formula: C₃H₁₁NO₇P₂

Color and Shape: Neat

Molecular weight: 235.07

Ref: TR-P172490

Pamidronic acid

CAS: 40391-99-9

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 235.06900024414062

Ref: 10-F240165

Pamidronic acid

CAS: 40391-99-9

Pamidronic acid is a monosodium salt that inhibits the production of proteins by binding to the enzyme protein phosphatase. It has been shown to be an effective chemotherapeutic treatment in a number of animal models and human clinical trials for various cancers, including myeloma, squamous carcinoma, and bone cancer. Pamidronic acid also prevents the proliferation of tumor cells in culture via inhibition of DNA synthesis and RNA synthesis. This drug binds to estrogen receptors on the surface of some cancer cells, thereby inhibiting their response to estradiol benzoate (EB) stimulation. This leads to decreased tumor growth in preclinical models.

Formula: C₃H₁₁NO₇P₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 235.07 g/mol

Ref: 3D-FP32121