CAS 404-82-0

Fenfluramine hydrochloride

Description:

Fenfluramine hydrochloride is a synthetic compound primarily known for its use as an appetite suppressant in the treatment of obesity. It belongs to the class of phenethylamines and is structurally related to amphetamines. The substance is characterized by its ability to increase serotonin levels in the brain, which contributes to its appetite-suppressing effects. Fenfluramine hydrochloride is typically presented as a white to off-white crystalline powder, soluble in water and alcohol. Its chemical formula is C9H14ClN, and it has a molecular weight of approximately 175.67 g/mol. While it was once widely prescribed, concerns regarding its safety profile, particularly its association with valvular heart disease and pulmonary hypertension, led to its withdrawal from the market in many countries. As a result, fenfluramine hydrochloride is now primarily used in research settings rather than as a therapeutic agent. Its pharmacological effects and potential side effects continue to be subjects of study in the field of pharmacology and toxicology.

Formula: C₁₂H₁₆F₃N·ClH

InChI: InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H

InChI key: InChIKey=ZXKXJHAOUFHNAS-UHFFFAOYSA-N

SMILES: C(C(NCC)C)C1=CC(C(F)(F)F)=CC=C1.Cl

Synonyms:

• (±)-Fenfluramine chloride
• 1-(m-Trifluoromethylphenyl)-2-(ethylamino)propane hydrochloride
• Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-, hydrochloride
• Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-, hydrochloride (1:1)
• Fenfluramine HCl
• Fintepla
• Ganal
• Hhr-965
• N-Ethyl-α-methyl-m-(trifluoromethyl)phenethylamine hydrochloride
• N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine hydrochloride (1:1)
• Phenethylamine, N-ethyl-α-methyl-m-(trifluoromethyl)-, hydrochloride
• Ponderal
• Ponderax
• Ponderex
• Pondimin
• Pondmin
• Racemic fenfluramine hydrochloride
• S 768
• Zx 008

Fenfluramine Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 404-82-0

Color and Shape: Colourless

Ref: 61-AMP0608.00-01

Fenfluramine Hydrochloride

CAS: 404-82-0

Color and Shape: Neat

Ref: 61-FOR0608.00

Fenfluramine hydrochloride

CAS: 404-82-0

Formula: C₁₂H₁₇ClF₃N

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 267.72

Ref: 7W-GP7074

Fenfluramine HCl

CAS: 404-82-0

Formula: C₁₂H₁₆F₃N·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 231.26 36.46

Ref: 4Z-F-108001

(+/-)-Fenfluramine-d5 HCl(N-ethyl-d5)

CAS: 1216927-29-5, 404-82-0

Purity: 98 atom % D

Molecular weight: 272.75

Ref: 3U-D7886

d,l-Fenfluramine.HCl, 1mg/ml in Methanol (as free base)

CAS: 404-82-0

Color and Shape: Single Solution

Ref: LP-FEF-872-HC-1LM

Fenfluramine HCl

Controlled Product

CAS: 404-82-0

Formula: C₁₂H₁₆F₃N·ClH

Color and Shape: Neat

Molecular weight: 267.72

Ref: 04-C13468000

Fenfluramine Hydrochloride

Controlled Product

CAS: 404-82-0

Formula: C₁₂H₁₆F₃N·ClH

Color and Shape: White

Molecular weight: 267.72

Ref: 86-MM0608.00

d,l-Fenfluramine.HCl

CAS: 404-82-0

Color and Shape: Neat

Ref: LP-FEF-872-HC-10

Fenfluramine hydrochloride 100 µg/mL in Acetonitrile

Controlled Product

CAS: 404-82-0

Formula: C₁₂H₁₆F₃N·ClH

Color and Shape: Single Solution

Molecular weight: 267.72

Ref: 04-XA13468000AL

DL-Fenfluramine Hydrochloride

Controlled Product

CAS: 404-82-0

Stability Hygroscopic
Applications N-​Ethyl-​α-​methyl-​3-​(trifluoromethyl)​-benzeneethanamine hydrochloride has been used in case studies for the study of impulsivity, motor skills, and anxiogenic effects in the neuroscience community.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Whitney, K.N., et al.: Exp. Clin. Psychopharm., 21, 345-54 (2013); Arrant, A.E., et al.: Neuropharmacology, 65, 213-22 (2013)

Formula: C₁₂H₁₆F₃N·ClH

Color and Shape: White

Molecular weight: 267.72

Ref: TR-F245605

Fenfluramine hydrochloride

Controlled Product

CAS: 404-82-0

A serotonin reuptake inhibitor. An anorectic agent, due to its appetite-suppressing actions. Norfenfluramine, its major metabolite, is an agonist of 5-HT2C receptors. Anti-seizure effect of fenfluramine has been demonstrated in patients with Dravet syndrome.

Formula: C₁₂H₁₇ClF₃N

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 267.72 g/mol

Ref: 3D-FF30618

rac-Fenfluramine-D11 Hydrochloride

Controlled Product

CAS: 404-82-0

Applications rac-Fenfluramine-D10 hydrochloride is a labelled analogue of rac-Fenfluramine hydrochloride.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Formula: C₁₂D₁₁H₅F₃N·HCl

Color and Shape: Neat

Molecular weight: 278.79

Ref: TR-F247603