CAS 404874-94-8

(R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

Description:

(R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one, with the CAS number 404874-94-8, is a chiral compound that belongs to the class of oxazolidinones, which are characterized by a five-membered heterocyclic ring containing oxygen and nitrogen. This specific compound features a phenyl group and a fluorinated aromatic moiety, which can influence its biological activity and pharmacokinetic properties. The presence of a hydroxyl group and a chiral center contributes to its potential as a pharmaceutical agent, possibly exhibiting antibacterial or anti-inflammatory properties. The stereochemistry indicated by the (R) and (S) designations suggests that the compound may have distinct biological activities based on its configuration. Additionally, the fluorine atom can enhance lipophilicity and metabolic stability, making it a subject of interest in medicinal chemistry. Overall, this compound's unique structural features may lead to specific interactions with biological targets, warranting further investigation for therapeutic applications.

Formula: C₂₀H₂₀FNO₄

Synonyms:

• 2-Oxazolidinone, 3-[(5S)-5-(4-fluorophenyl)-5-hydroxy-1-oxopentyl]-4-phenyl-, (4R)-
• Ezetimibe Impurity Z
• Ezetimibe Impurity N
• (4R)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
• Ezetimibe-13
• (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one
• Ezetimibe impuriry 15/(R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

Ezetimibe Impurity 26

CAS: 404874-94-8

Formula: C₂₀H₂₀FNO₄

Color and Shape: White To Off-White Solid

Molecular weight: 357.38

Ref: 4Z-E-0650

(R)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

Controlled Product

CAS: 404874-94-8

Applications (R)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one is a key intermediate in the preparation of Ezetimibe for treating high cholesterol.
References Fu, X., et al.: Tetrahedron Lett., 44, 801 (2003); Wang, B., et al.: From Faming Zhuanli Shenqing (2016), CN 105566375 A 20160511

Formula: C₂₀H₂₀FNO₄

Color and Shape: Neat

Molecular weight: 348.413

Ref: TR-F597720

Ezetimibe Impurity 2

CAS: 404874-94-8

Formula: C₂₀H₂₀FNO₄

Molecular weight: 357.4

Ref: ST-EA-CP-E6067