CAS 404951-53-7: 3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid

Description: 3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid, with CAS number 404951-53-7, is a synthetic compound characterized by its complex structure, which includes a hydroxamic acid functional group. This compound features an indole moiety, which is known for its biological activity, particularly in medicinal chemistry. The presence of the hydroxamic acid group suggests potential applications in enzyme inhibition, particularly in metalloprotein interactions, as hydroxamic acids are known to chelate metal ions. The compound's design incorporates a phenyl ring and an ethylamine side chain, which may enhance its solubility and bioavailability. Additionally, the presence of a hydroxyethyl group may contribute to its pharmacokinetic properties. Overall, this compound is of interest in research contexts, particularly in the development of therapeutic agents targeting specific biological pathways. Its unique structural features may also provide insights into structure-activity relationships in drug design.

Formula: C₂₂H₂₅N₃O₃

InChI: InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+

InChI key: InChIKey=BWDQBBCUWLSASG-MDZDMXLPSA-N

SMILES: O=C(C=CC1=CC=C(C=C1)CN(CCO)CCC2=CNC=3C=CC=CC32)NO

Synonyms:

• (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
• (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
• 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
• Dacinostat
• Laq-824
• Nvp-Laq-824

2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-

CAS: 404951-53-7

• Formula: C₂₂H₂₅N₃O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 379.4522

Dacinostat

CAS: 404951-53-7

• Purity: 99.77%
• Molecular weight: 379.45g/mol

Dacinostat

CAS: 404951-53-7

LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is …

• Formula: C₂₂H₂₅N₃O₃
• Purity: 95.28% - 95.28%
• Color and Shape: Solid
• Molecular weight: 379.45

Dacinostat

CAS: 404951-53-7

• Formula: C₂₂H₂₅N₃O₃
• Color and Shape: Neat
• Molecular weight: 379.452

Dacinostat

CAS: 404951-53-7

Inhibitor of histone deacetylases HDAC1 and HDAC2

• Formula: C₂₂H₂₅N₃O₃
• Purity: Min. 95%
• Molecular weight: 379.45 g/mol