CAS 404951-53-7

3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid

Description:

3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid, with CAS number 404951-53-7, is a synthetic compound characterized by its complex structure, which includes a hydroxamic acid functional group. This compound features an indole moiety, which is known for its biological activity, particularly in medicinal chemistry. The presence of the hydroxamic acid group suggests potential applications in enzyme inhibition, particularly in metalloprotein interactions, as hydroxamic acids are known to chelate metal ions. The compound's design incorporates a phenyl ring and an ethylamine side chain, which may enhance its solubility and bioavailability. Additionally, the presence of a hydroxyethyl group may contribute to its pharmacokinetic properties. Overall, this compound is of interest in research contexts, particularly in the development of therapeutic agents targeting specific biological pathways. Its unique structural features may also provide insights into structure-activity relationships in drug design.

Formula: C₂₂H₂₅N₃O₃

InChI: InChI=1/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+

InChI key: InChIKey=BWDQBBCUWLSASG-MDZDMXLPSA-N

SMILES: C(CN(CC1=CC=C(/C=C/C(NO)=O)C=C1)CCO)C=2C=3C(NC2)=CC=CC3

Synonyms:

• (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
• (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
• 2-Propenamide, N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-, (2E)-
• Dacinostat
• Laq-824
• Nvp-Laq-824
• (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide
• Dacinostat (NVP-LAQ824, LAQ824)
• NVP-LAQ824,Dacinostat
• LAQ824 (NVP-LAQ824)
• NVP-LAQ824
• Dacinostat(NVP-LAQ 824)
• LAQ824(NVP-LAQ824,Dacinostat)
• NVP-LAQ824; LAQ824; LAQ 824; LAQ-824
• CS-1101
• 3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid
• Dacinostat(LAQ824)
• LAQ824 (Dacinostat)

(2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide

CAS: 404951-53-7

Formula: C₂₂H₂₅N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 379.4522

Ref: IN-DA00BXVU

Dacinostat

CAS: 404951-53-7

Dacinostat

Purity: ≥95%

Molecular weight: 379.45g/mol

Ref: 54-BUP12144

Dacinostat

CAS: 404951-53-7

LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.

Formula: C₂₂H₂₅N₃O₃

Purity: 95.28% - 97.88%

Color and Shape: Solid

Molecular weight: 379.45

Ref: TM-T2454

Dacinostat

Controlled Product

CAS: 404951-53-7

Formula: C₂₂H₂₅N₃O₃

Color and Shape: Neat

Molecular weight: 379.452

Ref: TR-D101580

Dacinostat

CAS: 404951-53-7

Inhibitor of histone deacetylases HDAC1 and HDAC2

Formula: C₂₂H₂₅N₃O₃

Purity: Min. 95%

Molecular weight: 379.45 g/mol

Ref: 3D-FD43358