CHIR-124, with the CAS number 405168-58-3, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of certain protein kinases. It is characterized by its ability to modulate signaling pathways involved in cell proliferation and survival, making it a candidate for therapeutic applications in cancer treatment. The compound typically exhibits a specific mechanism of action that targets the ATP-binding site of kinases, thereby interfering with their activity. CHIR-124 is often studied in the context of its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are crucial for understanding its efficacy and safety profile. Additionally, its chemical structure may include functional groups that contribute to its biological activity and solubility. As with many investigational compounds, ongoing research aims to elucidate its full potential and optimize its use in clinical settings.

CHIR-124

405168-58-3: CHIR-124, with the CAS number 405168-58-3, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its role as a selective inhibitor of certain protein kinases. It is characterized by its ability to modulate signaling pathways involved in cell proliferation and survival, making it a candidate for therapeutic applications in cancer treatment. The compound typically exhibits a specific mechanism of action that targets the ATP-binding site of kinases, thereby interfering with their activity. CHIR-124 is often studied in the context of its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are crucial for understanding its efficacy and safety profile. Additionally, its chemical structure may include functional groups that contribute to its biological activity and solubility. As with many investigational compounds, ongoing research aims to elucidate its full potential and optimize its use in clinical settings.

CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.

CAS 405168-58-3

CHIR-124

CHIR-124

Ref: 54-BUP09411

CHIR-124

Ref: TM-T6350