CAS 4055-39-4

Mitomycin A

Description:

Mitomycin A is a naturally occurring antibiotic and antitumor agent derived from the bacterium Streptomyces caespitosus. It is classified as a bioreductive alkylating agent, which means it can undergo reduction in hypoxic conditions, leading to the formation of reactive species that can bind to DNA and inhibit cell division. This mechanism makes it particularly effective against rapidly dividing cancer cells. Mitomycin A exhibits a complex structure characterized by a quinone moiety, which is crucial for its biological activity. It is known for its cytotoxic properties and has been utilized in the treatment of various cancers, including bladder and breast cancer. However, its use is limited due to potential side effects, including myelosuppression and gastrointestinal toxicity. Mitomycin A is typically administered intravenously and requires careful monitoring due to its potent effects and the risk of cumulative toxicity. As with many chemotherapeutic agents, its application is often part of a combination therapy to enhance efficacy while minimizing adverse effects.

Formula: C₁₆H₁₉N₃O₆

InChI: InChI=1S/C16H19N3O6/c1-6-11(20)10-9(12(21)13(6)23-2)7(5-25-15(17)22)16(24-3)14-8(18-14)4-19(10)16/h7-8,14,18H,4-5H2,1-3H3,(H2,17,22)/t7-,8+,14+,16-/m1/s1

InChI key: InChIKey=HYFMSAFINFJTFH-NGSRAFSJSA-N

SMILES: O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(OC)=C(C)C3=O)C[C@]4([C@@]2(N4)[H])[H]

Synonyms:

• (1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione
• 4055-39-4
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester)
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methyl-, (1aS,8S,8aR,8bS)-
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methyl-, [1aS-(1aα,8β,8aα,8bα)]-
• Mitomycin A
• NSC 75986

Mitomycin A

CAS: 4055-39-4

Mitomycin A

Purity: 98%

Molecular weight: 349.34g/mol

Ref: 54-OR1075644

Mitomycin EP Impurity B (Mitomycin A)

CAS: 4055-39-4

Formula: C₁₆H₁₉N₃O₆

Molecular weight: 349.34

Ref: 4Z-M-843

Mitomycin A

CAS: 4055-39-4

Mitomycin A is a cytotoxic antibiotic derived from Streptomyces sp. with anticancer activity activity.Mitomycin A is used in the study of solid cancers.

Formula: C₁₆H₁₉N₃O₆

Purity: 98%

Color and Shape: Red-Violet Crystals

Molecular weight: 349.34

Ref: TM-T36705

Mitomycin A

CAS: 4055-39-4

Impurity Mitomycin EP Impurity B
Applications Mitomycin A (Mitomycin EP Impurity B) is the 6-methoxy analog of Mitomycin C and an antitumor antibiotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Kishi, Y., et al.: J. Nat. Prod., 42, 549 (1979),

Formula: C₁₆H₁₉N₃O₆

Color and Shape: Neat

Molecular weight: 349.34

Ref: TR-M371890

Mitomycin A

CAS: 4055-39-4

Mitomycin A is an antitumor antibiotic with action on DNA cross-linking to inhibit replication and is used for treating various cancers and in research applications.

Formula: C₁₆H₁₉N₃O₆

Purity: Min. 95%

Color and Shape: Purple Powder

Molecular weight: 349.34 g/mol

Ref: 3D-AM26018

Mitomycin EP Impurity B

CAS: 4055-39-4

Formula: C₁₆H₁₉N₃O₆

Molecular weight: 349.3

Ref: ST-EA-CP-M86002