CAS 40615-39-2

5′-O-(4,4′-Dimethoxytrityl)thymidine

Description:

5′-O-(4,4′-Dimethoxytrityl)thymidine is a modified nucleoside that plays a significant role in the field of molecular biology, particularly in the synthesis of oligonucleotides. This compound features a thymidine base, which is one of the four nucleobases in DNA, and is modified at the 5′ position with a dimethoxytrityl (DMT) protecting group. The DMT group is commonly used in solid-phase DNA synthesis as it provides a means to protect the hydroxyl group during the synthesis process, allowing for the sequential addition of nucleotides. The presence of two methoxy groups in the DMT moiety enhances the stability and solubility of the compound. In terms of its physical properties, 5′-O-(4,4′-Dimethoxytrityl)thymidine is typically a white to off-white solid, and it is soluble in organic solvents such as dichloromethane and methanol. Its chemical structure allows for specific reactivity, making it a valuable intermediate in the production of synthetic DNA and RNA sequences.

Formula: C₃₁H₃₂N₂O₇

InChI: InChI=1S/C31H32N2O7/c1-20-18-33(30(36)32-29(20)35)28-17-26(34)27(40-28)19-39-31(21-7-5-4-6-8-21,22-9-13-24(37-2)14-10-22)23-11-15-25(38-3)16-12-23/h4-16,18,26-28,34H,17,19H2,1-3H3,(H,32,35,36)/t26-,27+,28+/m0/s1

InChI key: InChIKey=UBTJZUKVKGZHAD-UPRLRBBYSA-N

SMILES: C(OC[C@H]1O[C@H](C[C@@H]1O)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• 1-{(3xi)-5-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2-deoxy-beta-D-glycero-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione
• 5'-Dimethoxytrityl Thymidine
• 5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxythymidine
• 5'-O-(4,4'-Dimethoxytrityl)Thymidine
• 5'-O-(Dimethoxytrityl)-Thymidine
• 5'-O-Dimethoxytrityl-Deoxythymidine
• 5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxythymidine
• 5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]thymidine
• 5’-O-[Bis(4-Methoxyphenyl)Phenylmethyl]-Thymidin
• 5′-O-(Di-p-methoxytrityl)thymidine
• 5′-O-(p,p′-Dimethoxytrityl)thymidine
• 5′-O-[Bis(4-methoxyphenyl)phenylmethyl]thymidine
• DMT-dT
• Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-

5'-O-(4,4'-Dimethoxytrityl)thymidine

CAS: 40615-39-2

Formula: C₃₁H₃₂N₂O₇

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 544.60

Ref: 3B-D3566

5'-O-(4,4'-Dimethoxytrityl)thymidine, 98+%

CAS: 40615-39-2

5'-O-(4,4'-Dimethoxytrityl)thymidine is used in the solid-phase synthesis of polynucleotides and polythymidylic acids by the block coupling phosphotriester method. Further, it is used in the stereoselective synthesis of 3'-deoxy-3'-threo-hydroxymethyl nucleoside. In addition to this, it is used as a

Formula: C₃₁H₃₂N₂O₇

Purity: 98+%

Color and Shape: White to pale cream, Powder or crystalline powder or crystals

Molecular weight: 544.60

Ref: 02-044815

Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-

CAS: 40615-39-2

Formula: C₃₁H₃₂N₂O₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 544.5950

Ref: IN-DA00I7YV

5''-O-(4,4''-Dimethoxytrityl)thymidine (DMT-T)

CAS: 40615-39-2

Formula: C₃₁H₃₂N₂O₇

Molecular weight: 544.60

Ref: 7W-GE4718

5-O-(4,4-Dimethoxytrityl)thymidine

CAS: 40615-39-2

5-O-(4,4-Dimethoxytrityl)thymidine

Formula: C₃₁H₃₂N₂O₇

Purity: 98%

Color and Shape: white powder

Molecular weight: 544.59g/mol

Ref: 54-OR9495

5'-O-DMT-dT

CAS: 40615-39-2

5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.

Formula: C₃₁H₃₂N₂O₇

Color and Shape: White Powder

Molecular weight: 544.59

Ref: TM-T40506

5’-O-(4,4’-Dimethoxytrityl)thymidine

Controlled Product

CAS: 40615-39-2

Applications 5’-O-(4,4’-Dimethoxytrityl)thymidine (cas# 40615-39-2) is a compound useful in organic synthesis.

Formula: C₃₁H₃₂N₂O₇

Color and Shape: White To Off-White

Molecular weight: 544.60

Ref: TR-D460775

5'-O-DMT-thymidine

CAS: 40615-39-2

5’-O-DMT-thymidine is also known as 5’-O-(4,4’-dimethoxytrityl)thymidine. It is a key deoxynucleoside building block that is protected with a dimethoxytrityl group in the 5-O-position of the deoxy-ribose moiety, leaving the 3-hydroxyl free for modification. It is used a convenient starting point for nucleotide synthesis. 5’-O-DMT-thymidine can be converted into 3’-O-phosphoramidite derivatives for oligonucleotide synthesis. Additionally, 5’-O-DMT-thymidine can be converted into more stable 1-N-protected derivatives.

Formula: C₃₁H₃₂N₂O₇

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 544.6 g/mol

Ref: 3D-ND03361

dmt-t

CAS: 40615-39-2

Formula: C₃₁H₃₂N₂O₇

Purity: 95%

Color and Shape: Solid

Molecular weight: 544.604

Ref: 10-F045324