CAS 40732-48-7

Guanosine, cyclic 3′,5′-(hydrogen phosphate), sodium salt (1:1)

Description:

Guanosine, cyclic 3′,5′-(hydrogen phosphate), sodium salt (1:1), commonly referred to as cyclic GMP (cGMP), is a nucleotide derivative that plays a crucial role in various biological processes. It is characterized by its cyclic structure, which consists of a guanosine base linked to a phosphate group through a cyclic bond, specifically between the 3' and 5' positions. This cyclic form is essential for its function as a secondary messenger in signal transduction pathways, particularly in response to hormones and neurotransmitters. The sodium salt form enhances its solubility in aqueous solutions, making it suitable for various biochemical applications. cGMP is involved in regulating smooth muscle relaxation, neuronal signaling, and cellular responses to nitric oxide. Its stability and reactivity are influenced by environmental factors such as pH and temperature. Overall, cGMP is a vital molecule in cellular signaling, influencing processes such as vasodilation and neurotransmission, and is a subject of interest in pharmacological research and therapeutic applications.

Formula: C₁₀H₁₂N₅O₇P·Na

InChI: InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/t3-,5-,6-,9-;/m1./s1

InChI key: InChIKey=AXHGWWQNGZIPRX-GWTDSMLYSA-N

SMILES: O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H])NC(N)=N1.[Na]

Synonyms:

• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, guanosine deriv.
• Cyclic 3',5'-guanosine monophosphate monosodium salt
• Cyclic 3′,5′-guanosine monophosphate monosodium salt
• Guanosine 3':5'-Cyclic Monophosphate Sodium Salt
• Guanosine monophosphate monosodium salt
• Guanosine, cyclic 3′,5′-(hydrogen phosphate), monosodium salt
• Guanosine, cyclic 3′,5′-(hydrogen phosphate), sodium salt (1:1)
• Monosodium-GMP

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

CAS: 40732-48-7

Formula: C₁₀H₁₁N₅NaO₇P

Purity: 99%

Color and Shape: Solid

Molecular weight: 367.1872

Ref: IN-DA00I7ZN

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

CAS: 40732-48-7

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

Purity: ≥98%

Molecular weight: 367.19g/mol

Ref: 54-BUP10378

Guanosine 3'',5''-cyclic monophosphate sodium salt

CAS: 40732-48-7

Formula: C₁₀H₁₁N₅NaO₇P

Molecular weight: 367.19

Ref: 7W-GN8139

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

CAS: 40732-48-7

cGMP sodium salt, a second messenger, regulates various hormones, activates PKG, and affects muscle relaxation and energy balance.

Formula: C₁₀H₁₁N₅NaO₇P

Purity: 99.11% - 99.95%

Color and Shape: White Powder / White To Off-White Solid

Molecular weight: 367.19

Ref: TM-T5065

Guanosine 3',5'-Cyclic Monophosphate-13C5 Sodium Salt

CAS: 40732-48-7

Formula: C₅₁₃C₅H₁₁N₅NaO₇P

Color and Shape: Neat

Molecular weight: 372.15

Ref: TR-G837963

Guanosine 3’,5’-Cyclic Monophosphate Sodium Salt

Controlled Product

CAS: 40732-48-7

Applications Guanosine 3’,5’-Cyclic Monophosphate is a substituted Guanosine having cyclic phosphodiesterase activity.
References Tazawa, et al.: Biochemistry, 11, 4931 (1972),

Formula: C₁₀H₁₁N₅O₇P·Na

Color and Shape: Neat

Molecular weight: 367.19

Ref: TR-G837960

Guanosine 3',5'-Cyclic-13C,15N2 Monophosphate

CAS: 40732-48-7

Applications Labelled Guanosine 3’,5’-Cyclic Monophosphate (G837960). Guanosine 3’,5’-Cyclic Monophosphate is a substituted Guanosine (G837900) having cyclic phosphodiesterase activity.
References Tazawa, et al.: Biochemistry, 11, 4931 (1972),

Formula: C₉₁₃CH₁₂N₃₁₅N₂O₇P

Color and Shape: White To Off-White

Molecular weight: 348.18

Ref: TR-G837962

Guanosine 3',5'-cyclic monophosphate sodium salt

CAS: 40732-48-7

Guanosine 3',5'-cyclic monophosphate sodium salt (cGMP) is a cyclic nucleotide that is involved in the regulation of many cellular processes. It binds to specific guanine nucleotide-binding proteins (G proteins) and activates protein kinase A, which regulates glucose metabolism and energy production. cGMP also affects neuronal death, axonal growth, and bowel disease by acting as a cyclase inhibitor or activating the immune system. It has been shown to reduce the severity of infectious diseases such as HIV and malaria by activating the immune system.

Formula: C₁₀H₁₁N₅NaO₇P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 367.19 g/mol

Ref: 3D-NG08975

cGMP sodium salt - Bio-X ™

CAS: 40732-48-7

Cyclic guanosine monophosphate (cyclic GMP) is a guanine nucleotide that is a cellular regulatory agent and is used to increase the levels of various hormones. This molecule is said to increase levels of hormones such as insulin, oxytocin and acetylcholine. Studies have found this molecule to also activate protein kinases.

Formula: C₁₀H₁₂N₅O₇P•Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 368.2 g/mol

Ref: 3D-BG164518

Guanosine-3′:5′-cyclic monophosphate monosodium salt

CAS: 40732-48-7

Formula: C₁₀H₁₁N₅NaO₇P

Purity: 98%

Color and Shape: Solid

Molecular weight: 367.19

Ref: 10-F492589

Guanosine 3’,5’-Cyclic-13C3,15N4 Monophosphate

Controlled Product

CAS: 40732-48-7

Applications Guanosine 3’,5’-Cyclic-13C3,15N4 Monophosphate, is the labeled analogue of Guanosine 3’,5’-Cyclic Monophosphate (G837960), a substituted Guanosine having cyclic phosphodiesterase activity.
References Tazawa, et al.: Biochemistry, 11, 4931 (1972),

Formula: C₃C₇H₁₂₁₅N₄NO₇P

Color and Shape: Neat

Molecular weight: 352.157

Ref: TR-G837964