CAS 40733-28-6: 5′-O-[(1,1-Dimethylethyl)dimethylsilyl]thymidine

Description: 5′-O-[(1,1-Dimethylethyl)dimethylsilyl]thymidine, with the CAS number 40733-28-6, is a modified nucleoside derivative of thymidine. This compound features a silyl protecting group, specifically a tert-butyldimethylsilyl (TBDMS) group, which enhances its stability and solubility in organic solvents. The presence of the silyl group allows for selective protection of the hydroxyl group at the 5′ position, making it useful in various synthetic applications, particularly in the field of nucleic acid chemistry. The compound is typically utilized in the synthesis of oligonucleotides and other nucleoside analogs, facilitating the introduction of modifications that can enhance the properties of the resulting molecules. Its structural characteristics contribute to its reactivity and compatibility with various chemical reactions, making it a valuable intermediate in biochemical research and pharmaceutical development. As with many silyl derivatives, it is important to handle this compound with care, as it may react with moisture and other nucleophiles, leading to the release of the silyl group.

Formula: C₁₆H₂₈N₂O₅Si

InChI: InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(19)12(23-13)9-22-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1

InChI key: InChIKey=IJWIJLIIOKZJMS-YNEHKIRRSA-N

SMILES: O=C1NC(=O)N(C=C1C)C2OC(CO[Si](C)(C)C(C)(C)C)C(O)C2

Synonyms:

• 1-Piperazinecarboxylic Acid, 4-(5-Carboxy-2-Pyridinyl)-, 1-(1,1-Dimethylethyl) Ester
• 1-[(2S,4R,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
• 5′-O-(tert-Butyldimethylsilyl)deoxythymidine
• 5′-O-[(1,1-Dimethylethyl)dimethylsilyl]thymidine
• 5′-O-tert-Butyldimethylsilylthymidine
• 6-(4-{[(2-Methyl-2-propanyl)oxy]carbonyl}-1-piperazinyl)nicotinic acid
• 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinic acid
• Thymidine, 5′-O-[(1,1-dimethylethyl)dimethylsilyl]-

5'-O-(tert-Butyldimethylsilyl)thymidine, 97+%

CAS: 40733-28-6

5'-O-(tert-Butyldimethylsilyl)thymidine is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part …

• Formula: C₁₆H₂₈N₂O₅Si
• Purity: 97+%
• Color and Shape: Powder, White to off-white
• Molecular weight: 356.49

5'-O-TERT-BUTYLDIMETHYLSILYL-THYMIDINE

CAS: 40733-28-6

• Formula: C₁₆H₂₈N₂O₅Si
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 356.4894

5'-O-TBDMS-dT

CAS: 40733-28-6

5’-O-TBDMS-dT is a nucleoside with protective and modification effects.

• Formula: C₁₆H₂₈N₂O₅Si
• Color and Shape: Liquid
• Molecular weight: 356.49

5'-O-(tert-Butyldimethylsilyl)thymidine

CAS: 40733-28-6

• Formula: C₁₆H₂₈N₂O₅Si
• Purity: 99%
• Color and Shape: white powder
• Molecular weight: 356.49g/mol

5'-O-tert-Butyldimethylsilylthymidine

CAS: 40733-28-6

Please enquire for more information about 5'-O-tert-Butyldimethylsilylthymidine including the price, delivery time and more detailed …

• Formula: C₁₆H₂₈N₂O₅Si
• Purity: Min. 95%
• Molecular weight: 356.5 g/mol