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CAS 40922-77-8

:

Leucomycin V, 3-acetate 4B-(3-methylbutanoate) 9-propanoate

Description:
Leucomycin V, 3-acetate 4B-(3-methylbutanoate) 9-propanoate, identified by its CAS number 40922-77-8, is a semi-synthetic antibiotic derived from the natural product leucomycin, which is produced by the bacterium Streptomyces. This compound exhibits characteristics typical of macrolide antibiotics, including a large lactone ring structure that contributes to its antibacterial activity. It is primarily effective against Gram-positive bacteria and some Gram-negative bacteria, making it useful in treating various bacterial infections. The presence of acetate and propanoate groups enhances its pharmacological properties, potentially improving its solubility and bioavailability. Leucomycin V is known for its mechanism of action, which involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. This compound is generally administered via injection or orally, depending on the formulation. As with many antibiotics, it is essential to use leucomycin derivatives judiciously to minimize the risk of developing antibiotic resistance.
Formula:C45H73NO16
InChI:InChI=1/C45H73NO16/c1-13-34(49)59-32-18-16-14-15-17-27(5)55-36(51)23-33(58-30(8)48)42(54-12)41(31(19-20-47)22-26(32)4)62-44-39(52)38(46(10)11)40(28(6)57-44)61-37-24-45(9,53)43(29(7)56-37)60-35(50)21-25(2)3/h14-16,18,20,25-29,31-33,37-44,52-53H,13,17,19,21-24H2,1-12H3/b15-14-,18-16-
InChI key:InChIKey=NVBREHSOJSEKBQ-ZQMZUEOGSA-N
SMILES:O([C@@H]1[C@@H](OC)[C@H](OC(C)=O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](OC(CC)=O)[C@H](C)C[C@@H]1CC=O)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CC(C)C)=O)[C@H](C)O3)[C@@H](C)O2
Synonyms:
  • 10-Propionyljosamycin
  • 6-{[6-{[(11Z)-4-(acetyloxy)-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-10-(propanoyloxy)oxacyclohexadeca-11,13-dien-6-yl]oxy}-4-(dimethylamino)-5-hydroxy-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
  • 9-Propionyljosamycin
  • Josamy
  • Josaxin
  • Leucomycin V, 3-acetate 4<sup>B</sup>-(3-methylbutanoate) 9-propanoate
  • Oxacyclohexadecane, leucomycin V deriv.
  • Leucomycin V, 3-acetate 4B-(3-methylbutanoate) 9-propanoate
  • Josamycin propionate
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Found 4 products.
  • CymitQuimica logo
    EDQM - European Pharmacopoeia
    + Info

    JOSAMYCIN PROPIONATE CRS

    CAS:
    JOSAMYCIN PROPIONATE CRS
    Formula:C45H73NO16
    Color and Shape:Crystalline Powder. White. Light Yellow. Powder., Crystalline Powder. White. Light Yellow. Powder.
    Molecular weight:884.0582

    Ref: 41-Y0000042

    150mg
    115.00€
  • Josamycin Impurity 4-d5
    TLC
    + Info

    Josamycin Impurity 4-d5

    CAS:
    Formula:C45H68D5NO16
    Molecular weight:889.10

    Ref: 4Z-J-008014

    5mg
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    10mg
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    25mg
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    50mg
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    100mg
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  • Josamycin Impurity 4
    TLC
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    Josamycin Impurity 4

    CAS:
    Formula:C45H73NO16
    Molecular weight:884.07

    Ref: 4Z-J-008012

    5mg
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    10mg
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    25mg
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    50mg
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    100mg
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  • Josamycin Propionate
    TRC
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    Josamycin Propionate

    Controlled Product
    CAS:
    <p>Applications Josamycin Propionate is a macrolide antibiotic which is effective against strains of Streptomyces.<br>References Inouye, S. et al.: Curr. Chemother. Immunother., Proc. Int. Congr. Chemother., 2, 887 (1982)<br></p>
    Formula:C45H73NO16
    Color and Shape:Neat
    Molecular weight:884.058

    Ref: TR-J212033

    10mg
    130.00€
    25mg
    243.00€