CAS 410074-73-6

Amitifadine

Description:

Amitifadine, identified by its CAS number 410074-73-6, is a chemical compound that has garnered interest primarily in the field of pharmacology. It is classified as a novel antidepressant and is known for its unique mechanism of action, which involves the modulation of neurotransmitter systems, particularly serotonin, norepinephrine, and dopamine. This multi-target approach is thought to contribute to its potential efficacy in treating mood disorders. Amitifadine is characterized by its relatively low toxicity profile and is being investigated for its therapeutic effects in conditions such as major depressive disorder. The compound's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for understanding its clinical applications and potential side effects. As research continues, Amitifadine may offer new insights into the treatment of depression and related disorders, although further studies are necessary to fully elucidate its safety and efficacy in diverse populations.

Formula: C₁₁H₁₁Cl₂N

InChI: InChI=1S/C11H11Cl2N/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11/h1-3,8,14H,4-6H2/t8-,11+/m1/s1

InChI key: InChIKey=BSMNRYCSBFHEMQ-KCJUWKMLSA-N

SMILES: ClC=1C=C([C@]23[C@](C2)(CNC3)[H])C=CC1Cl

Synonyms:

• DOV 21947
• Amitifadine
• (1R,5S)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
• 3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-, (1R,5S)-
• EB 1010

Amitifadine

Controlled Product

CAS: 410074-73-6

Formula: C₁₁H₁₁Cl₂N

Color and Shape: Neat

Molecular weight: 228.118

Ref: TR-A633370

Amitifadine-d7

Controlled Product

CAS: 410074-73-6

Formula: C₁₁D₇H₄Cl₂N

Color and Shape: Neat

Molecular weight: 235.161

Ref: TR-A633372

Amitifadine

CAS: 410074-73-6

Amitifadine is a small molecule that inhibits protein interactions and has been used as a research tool. It has been shown to bind to the extracellular domain of the beta-2 adrenergic receptor, which is responsible for binding with endogenous catecholamines such as epinephrine and norepinephrine. Amitifadine also binds to the alpha-1 adrenergic receptor, but not as strongly. This drug has also been shown to bind to other receptors such as the angiotensin II type 1 receptor, serotonin type 3A receptor, and histamine H1 receptor.

Formula: C₁₁H₁₁Cl₂N

Purity: Min. 95%

Molecular weight: 228.11 g/mol

Ref: 3D-KRA07473

Amitifadine free base

CAS: 410074-73-6

Amitifadine (DOV-21947/EB-1010), an antidepressant SNDRI, curbs binge drinking and negative effects in animals with alcoholism-depression.

Formula: C₁₁H₁₁Cl₂N

Color and Shape: Solid

Molecular weight: 228.12

Ref: TM-T2092L