CAS 410528-02-8

Palovarotene

Description:

Palovarotene is a synthetic retinoid, primarily recognized for its role in modulating retinoic acid signaling pathways. It is characterized by its ability to selectively activate retinoic acid receptors, which are crucial in various biological processes, including cell differentiation and proliferation. Palovarotene has garnered attention for its potential therapeutic applications, particularly in the treatment of fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterized by abnormal bone growth. The compound is typically administered orally and has been studied for its efficacy in reducing heterotopic ossification. In terms of its chemical structure, palovarotene features a unique arrangement of carbon, hydrogen, and nitrogen atoms, contributing to its biological activity. Its pharmacokinetic properties include absorption, distribution, metabolism, and excretion, which are essential for understanding its therapeutic potential and safety profile. As with many retinoids, palovarotene may exhibit side effects, necessitating careful monitoring during treatment. Overall, its selective action on retinoic acid receptors positions palovarotene as a promising candidate in the field of targeted therapies.

Formula: C₂₇H₃₀N₂O₂

InChI: InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+

InChI key: InChIKey=YTFHCXIPDIHOIA-DHZHZOJOSA-N

SMILES: CC1(C)C=2C(=CC(/C=C/C3=CC=C(C(O)=O)C=C3)=C(CN4C=CC=N4)C2)C(C)(C)CC1

Synonyms:

• 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid
• 4-{(1E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoicacid
• Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]-
• Clm 001
• Ipn 60120
• R 667
• Ro 3300074
• Sohonos
• Palovarotene

Palovarotene

CAS: 410528-02-8

Formula: C₂₇H₃₀N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 414.5393

Ref: IN-DA00C6H0

palovarotene

CAS: 410528-02-8

palovarotene

Purity: ≥95%

Molecular weight: 414.54g/mol

Ref: 54-BUP05518

Palovarotene

CAS: 410528-02-8

Formula: C₂₇H₃₀N₂O₂

Molecular weight: 414.55

Ref: 4Z-P-100002

palovarotene

CAS: 410528-02-8

Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).

Formula: C₂₇H₃₀N₂O₂

Purity: 97.88% - 98.05%

Color and Shape: Solid

Molecular weight: 414.54

Ref: TM-T4538

Palovarotene

Controlled Product

CAS: 410528-02-8

Applications Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.
References Hind, M., et al.: Curr. Opinion Invest. Drugs, 10(11), 1243 (2009); Stolk, J., et al.: Therap. advances Respi. dise., 4, 319 (2010);

Formula: C₂₇H₃₀N₂O₂

Color and Shape: Neat

Molecular weight: 414.54

Ref: TR-P165900

Palovarotene-13C4

Controlled Product

CAS: 410528-02-8

Formula: C₄C₂₃H₃₀N₂O₂

Color and Shape: Neat

Molecular weight: 418.51

Ref: TR-P165902