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CAS 41094-07-9

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S-(2-hydroxy-5-nitrobenzyl)-6-*thioguanosine

Description:
S-(2-hydroxy-5-nitrobenzyl)-6-thioguanosine is a modified nucleoside that incorporates a thiol group, which enhances its potential for biochemical applications, particularly in the field of molecular biology and medicinal chemistry. This compound features a guanosine backbone, which is a purine nucleoside, and is characterized by the presence of a 2-hydroxy-5-nitrobenzyl moiety attached to the sulfur atom of the thiol group. The nitro group introduces electron-withdrawing characteristics, which can influence the compound's reactivity and interactions with biological targets. The hydroxyl group may also participate in hydrogen bonding, potentially affecting the compound's solubility and stability in aqueous environments. Overall, the unique structural features of S-(2-hydroxy-5-nitrobenzyl)-6-thioguanosine suggest that it may exhibit distinct pharmacological properties, making it of interest for further research in drug development and therapeutic applications.
Formula:C17H18N6O7S
InChI:InChI=1/C17H18N6O7S/c18-17-20-14-11(19-6-22(14)16-13(27)12(26)10(4-24)30-16)15(21-17)31-5-7-3-8(23(28)29)1-2-9(7)25/h1-3,6,10,12-13,16,24-27H,4-5H2,(H2,18,20,21)/t10-,12-,13-,16-/m1/s1
SMILES:c1cc(c(cc1N(=O)=O)CSc1c2c([nH]c(=N)n1)n(cn2)[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)O)O
Synonyms:
  • 2-Hydroxy-5-nitrobenzylthioguanosine
  • 2-Hydroxy-5-nitrobenzyl-6-thioguanosine
  • Hnbtg
  • Hydroxynitrobenzoylthioguanosine
  • Phenol, 2-(((2-amino-9-beta-D-ribofuranosyl-9H-purin-6-yl)thio)methyl)-4-nitro-
  • 6-[(2-hydroxy-5-nitrobenzyl)sulfanyl]-9-(beta-D-ribofuranosyl)-9H-purin-2-amine
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Found 2 products.
  • S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine
    Glentham
    + Info

    S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine

    CAS:
    Formula:C17H18N6O7S
    Molecular weight:450.43

    Ref: 7W-GN9938

    ne
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  • S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine
    Biosynth
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    S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine

    CAS:
    S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine is a benzodiazepine derivative that inhibits the uptake of uridine into cells. It binds to adenosine receptors and inhibits neurotransmission by preventing the release of the inhibitory neurotransmitter GABA. S-(2-Hydroxy-5-nitrobenzoyl)-6-thioguanosine also has an inhibitory effect on mitochondrial function, which may be due to its ability to bind with and inactivate mitochondrial enzyme succinate dehydrogenase. This drug is potent in inhibiting uptake assays, but has low potency and poor bioavailability as a result of its covalent linkages.
    Formula:C17H18N6O7S
    Purity:Min. 95%
    Molecular weight:450.43 g/mol

    Ref: 3D-NH08019

    25mg
    303.00€
    50mg
    414.00€