CAS 4111-54-0: Lithium diisopropylamide

Description: Lithium diisopropylamide (LDA) is a strong, non-nucleophilic base commonly used in organic synthesis, particularly for deprotonating weak acids and facilitating various reactions such as enolate formation. It is characterized by its lithium cation paired with the diisopropylamide anion, which enhances its basicity and steric hindrance, making it less reactive towards electrophiles. LDA is typically a white to off-white solid at room temperature and is soluble in polar aprotic solvents like tetrahydrofuran (THF) and dimethyl sulfoxide (DMSO). It is sensitive to moisture and air, requiring storage under inert atmospheres to maintain its stability. The compound is often utilized in the synthesis of complex organic molecules, including pharmaceuticals and agrochemicals, due to its ability to selectively deprotonate specific sites in substrates. Safety precautions are necessary when handling LDA, as it can react vigorously with water and other protic solvents, releasing heat and potentially causing hazardous situations.

Formula: C₆H₁₅N·Li

InChI: InChI=1S/C6H15N.Li/c1-5(2)7-6(3)4;/h5-7H,1-4H3;

InChI key: InChIKey=OVEHNNQXLPJPPL-UHFFFAOYSA-N

SMILES: [Li].N(C(C)C)C(C)C

Synonyms:

• (Diisopropylamino)lithium
• 2-Propanamine, N-(1-methylethyl)-, lithium salt (1:1)
• Diisopropilamiduro De Litio
• Diisopropylamidure de lithium
• Diisopropylamine, lithium salt
• LDA
• LDA (reagent)
• Lithiodiisopropylamine
• Lithium Diisopropylamide
• Lithium diisopropylamine
• Lithium, (diisopropylamino)-
• Lithiumdiisopropylamid
• N-(1-Methylethyl)-2-propanamine lithium salt
• N-Lithiodiisopropylamide
• 2-Propanamine, N-(1-methylethyl)-, lithium salt

Lithium Diisopropylamide

CAS: 4111-54-0

• Formula: C₆H₁₅LiN
• Color and Shape: Liquid
• Molecular weight: 108.1310

Lithium diisopropylamide, 2M solution in THF/n-Heptane

CAS: 4111-54-0

• Formula: (CH₃)₂CHNLi
• Color and Shape: Yellow-orange, or brown to red solution
• Molecular weight: 107.12

Lithium diisopropylamide, 2M sol. in THF/n-heptane/ethylbenzene, AcroSeal™

CAS: 100-41-4 109-99-9 142-82-5 4111-54-0

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₆H₁₄LiN
• Color and Shape: Dark yellow to orange to dark red-brown, If precipitation is present, gently mix, Clear to slightly hazy solution, atmosphere, May develop some turbidity or precipitate, precipitate back into solution under an inert
• Molecular weight: 107.13

Lithium diisopropylamide - 2.0 M in THF/ethylbenzene

CAS: 4111-54-0

2.0 M in THF/ethylbenzene

• Formula: C₆H₁₄LiN
• Purity: Min. 95%
• Color and Shape: Clear Liquid
• Molecular weight: 107.12 g/mol

Lithium diisopropylamide - 2.0M in THF/heptane/ethylbenzene

CAS: 4111-54-0

Lithium diisopropylamide is a compound that is used in the manufacture of pharmaceuticals. Lithium diisopropylamide …

• Formula: C₆H₁₄LiN
• Purity: Min. 95%
• Color and Shape: Solid
• Molecular weight: 107.12 g/mol