CAS 41372-20-7

Apomorphine hydrochloride hemihydrate

Description:

Apomorphine hydrochloride hemihydrate is a chemical compound primarily used in the treatment of Parkinson's disease and as an emetic. It is a derivative of morphine, characterized by its ability to stimulate dopamine receptors in the brain, which helps alleviate motor symptoms associated with Parkinson's. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for injection or subcutaneous administration. Its molecular formula includes a hydrochloride salt form, which enhances its stability and solubility. The hemihydrate form indicates that it contains half a molecule of water for each molecule of apomorphine hydrochloride, influencing its physical properties and stability. Due to its pharmacological effects, apomorphine hydrochloride hemihydrate must be used under medical supervision, as it can cause side effects such as nausea, vomiting, and dyskinesia. Proper storage conditions are essential to maintain its efficacy, typically requiring protection from light and moisture.

Formula: C₁₇H₁₇NO₂·ClHH₂O

InChI: InChI=1S/C17H17NO2.ClH.H2O/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;/h2-6,13,19-20H,7-9H2,1H3;1H;1H2/t13-;;/m1../s1

InChI key: InChIKey=DQQCJDBYNZMPOA-FFXKMJQXSA-N

SMILES: CN1[C@]2(C=3C(C=4C(C2)=CC=C(O)C4O)=CC=CC3CC1)[H].Cl.O

Synonyms:

• (R)-(-)-Apomorphine hydrochloride hemihydrate
• 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (R)-
• 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:2:1), (6aR)-
• Apomorphine hydrochloride hemihydrate
• 6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
• 4H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)-
• 200-360-0
• (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
• (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride hydrate (2:2:1)
• Uprima

Apomorphine Hydrochloride Hemihydrate

CAS: 41372-20-7

Color and Shape: Neat

Ref: 61-FOR0562.00

Apomorphine Hydrochloride Hemihydrate 1.0 mg/ml in Methanol (as anhydrous free base)

CAS: 41372-20-7

Color and Shape: Single Solution

Ref: 61-AMP0562.00-01

APOMORPHINE HYDROCHLORIDE HEMIHYDRATE CRS

CAS: 41372-20-7

APOMORPHINE HYDROCHLORIDE HEMIHYDRATE CRS

Formula: C₁₇H₁₇NO₂

Color and Shape: Removed

Molecular weight: 267.3224

Ref: 41-Y0001465

Apomorphine Hydrochloride

CAS: 41372-20-7

Drugs primarily affecting the central nervous system, nesoi

Formula: C₁₇H₁₇NO₂·HClH₂O

Color and Shape: White Yellow Grey Crystalline Powder

Molecular weight: 267.12593

Ref: 45-1041008

Apomorphine Hydrochloride Hemihydrate

Controlled Product

CAS: 41372-20-7

Formula: C₁₇H₁₇NO₂ClH·H₂O

Color and Shape: Neat

Molecular weight: 625.58

Ref: 86-MM0562.00

Apomorphine hydrochloride

CAS: 41372-20-7

Formula: C₁₇H₁₇NO₂·HCl·5(H₂O)

Purity: ≥ 98%

Color and Shape: White to grey powder

Molecular weight: 312.79

Ref: 7W-GP0822

(R)-Apomorphine Hydrochloride Hemihydrate

Controlled Product

CAS: 41372-20-7

Stability Hygroscopic, Light Sensitive
Applications Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970), Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991),

Formula: C₁₇H₁₇NO₂·2ClH·H₂O

Color and Shape: Neat

Molecular weight: 625.58

Ref: TR-A727500

(R)-Apomorphine hydrochloride hemihydrate

CAS: 41372-20-7

Apomorphine hydrochloride is the salt form of apomorphine, a morphine derivative D2 dopamine agonist. The high selectivity for D2, D3, D4 and D5 receptors makes apomorphine hydrochloride a possible drug candidate and it is in clinical trials for diagnosis and treatment of Parkinsons disease. Moreover, apomorphine and apomorphine hydrochloride have been investigated in diverse studies for treating movement disorders.

Formula: C₁₇H₁₇NO₂•HCl•(H₂O)₀

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 312.79 g/mol

Ref: 3D-FA17955