CAS 41451-75-6

Bruceantin

Description:

Bruceantin is a natural product derived from the plant Brucea javanica, known for its potential medicinal properties. It is classified as a complex alkaloid and exhibits a range of biological activities, including antitumor and antiviral effects. The compound has garnered interest in pharmacological research due to its ability to inhibit certain cancer cell lines and its potential use in traditional medicine. Chemically, Bruceantin is characterized by its unique structure, which includes multiple rings and functional groups that contribute to its biological activity. Its mechanism of action is thought to involve interference with cellular processes, although detailed studies are ongoing to fully elucidate its pharmacodynamics. Additionally, Bruceantin's solubility and stability in various solvents can influence its bioavailability and therapeutic efficacy. As research continues, Bruceantin may offer insights into new therapeutic avenues for cancer treatment and other diseases, highlighting the importance of natural products in drug discovery.

Formula: C₂₈H₃₆O₁₁

InChI: InChI=1S/C28H36O11/c1-11(2)12(3)7-17(30)39-20-22-27-10-37-28(22,25(35)36-6)23(33)19(32)21(27)26(5)9-15(29)18(31)13(4)14(26)8-16(27)38-24(20)34/h7,11,14,16,19-23,31-33H,8-10H2,1-6H3/b12-7+/t14-,16+,19+,20+,21+,22+,23-,26-,27+,28-/m0/s1

InChI key: InChIKey=IRQXZTBHNKVIRL-GOTQHHPNSA-N

SMILES: C(OC)(=O)[C@]12[C@]3([C@]4([C@@]([C@]5(C)[C@@](C[C@]4(OC(=O)[C@@H]3OC(/C=C(/C(C)C)\C)=O)[H])(C(C)=C(O)C(=O)C5)[H])([C@@H](O)[C@@H]1O)[H])CO2)[H]

Synonyms:

• 2H-3,11c-(Epoxymethano)phenanthro(10,1-bc)pyran, picras-3-en-21-oic acid deriv. (9CI)
• 2H-3,11c-(Epoxymethano)phenanthro[10,1-bc]pyran, picras-3-en-21-oic acid deriv.
• Methyl (11Beta,12Alpha,13Xi,15Beta)-15-[(3,4-Dimethylpent-2-Enoyl)Oxy]-3,11,12-Trihydroxy-2,16-Dioxo-13,20-Epoxypicras-3-En-21-Oate
• Nci 165563
• Nsc 165563
• Picras-3-en-21-oic acid, 15-((3,4-dimethyl-1-oxo-2-pentenyl)oxy)-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, (11beta,12alpha,15beta(E))- (9CI)
• Picras-3-en-21-oic acid, 15-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, [11β,12α,15β(E)]-
• Picras-3-en-21-oic acid, 15-[[(2E)-3,4-dimethyl-1-oxo-2-penten-1-yl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, (11β,12α,15β)-
• Picras-3-en-21-oic acid, 15-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxo-, methyl ester, (11β,12α,15β)-
• methyl (11beta,12alpha,13beta,15beta)-15-{[(2E)-3,4-dimethylpent-2-enoyl]oxy}-3,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicras-3-en-21-oate
• methyl (11beta,12alpha,15beta)-15-{[(2E)-3,4-dimethylpent-2-enoyl]oxy}-3,11,12-trihydroxy-2,16-dioxo-13,20-epoxypicras-3-en-21-oate

Bruceantin

CAS: 41451-75-6

Formula: C₂₈H₃₆O₁₁

Purity: 97%

Color and Shape: Solid

Molecular weight: 548.5788

Ref: IN-DA00C6F2

Bruceantin

CAS: 41451-75-6

Bruceantin

Purity: ≥98%

Molecular weight: 548.58g/mol

Ref: 54-BUP21314

Bruceantin

CAS: 41451-75-6

Formula: C₂₈H₃₆O₁₁

Molecular weight: 548.59

Ref: 7W-GY4183

Bruceantin

CAS: 41451-75-6

Bruceantin has antiviral activity, it can inhibit pepper mottle virus in pepper; it also shows high antimalarial activity. Bruceantin is an effective agent in controlling the proliferation, viability and migration of multiple myeloma cancer stem cells (CSCs) as well as angiogenesis in vitro. Bruceantin exhibits NF-κB p65 inhibition, and cytotoxic potential against HT-29, HeLa, and HL-60 cells .

Formula: C₂₈H₃₆O₁₁

Purity: 95%~99%

Molecular weight: 548.585

Ref: BP-BP3088

Bruceantin

Controlled Product

CAS: 41451-75-6

Applications Bruceantin is a pharmacological agent which has been shown to induce apoptosis in human promyelocytic leukemia cells. Antiamoebic agent.
References Bertani, S. et alExp. Parasitol., 130, 341 (2012); Ramirez-Galicia, G. et al.: Med. Chem. Res., 21, 2501 (2012);

Formula: C₂₈H₃₆O₁₁

Color and Shape: Neat

Molecular weight: 548.58

Ref: TR-B689310

Bruceantin

CAS: 41451-75-6

Bruceantin (NSC-165563) is a natural product isolated from Brucea antidysenterica.

Formula: C₂₈H₃₆O₁₁

Purity: 98.94%

Color and Shape: Solid

Molecular weight: 548.58

Ref: TM-TQ0213