CAS 4146-30-9

Neomycin B sulfate

Description:

Neomycin B sulfate is an aminoglycoside antibiotic derived from the bacterium *Streptomyces fradiae*. It is primarily used for its antibacterial properties, particularly against Gram-negative bacteria. The substance is characterized by its complex structure, which includes multiple amino sugars linked to a central aminocyclitol ring. Neomycin B sulfate is highly soluble in water, making it suitable for various pharmaceutical formulations, including topical and ophthalmic applications. It exhibits a broad spectrum of activity, particularly effective against infections caused by *Escherichia coli* and *Klebsiella pneumoniae*. However, its use is often limited due to potential nephrotoxicity and ototoxicity, especially with systemic administration. Neomycin B sulfate is also utilized in laboratory settings for selective inhibition of bacterial growth. Its mechanism of action involves binding to the bacterial ribosome, disrupting protein synthesis, which ultimately leads to cell death. As with all antibiotics, appropriate usage is crucial to mitigate the risk of developing antibiotic resistance.

Formula: C₂₃H₄₆N₆O₁₃·3H₂O₄S

InChI: InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key: InChIKey=OIXVKQDWLFHVGR-WQDIDPJDSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N

Synonyms:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-D-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3) (salt)
• Neomycin B sulfate
• Neomycin B trisulfate
• Neomycin B, sulfate (1:3) (salt)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3)
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:3) (salt)

FRAMYCETIN SULFATE CRS

CAS: 4146-30-9

FRAMYCETIN SULFATE CRS

Formula: C₂₃H₄₈N₆O₁₇S

Molecular weight: 712.7222

Ref: 41-F0450000

FRAMYCETIN SULFATE (NEOMYCIN B SULFATE) RS

CAS: 4146-30-9

FRAMYCETIN SULFATE (NEOMYCIN B SULFATE) RS

Ref: 41-ICRS0355

D-STREPTAMINE, O-2,6-DIAMINO-2,6-DIDEOXY-β-L-IDOPYRANOSYL-(1->3)-O-β-D-RIBOFURANOSYL-(1->5)-O-[2,6-DIAMINO-2,6-DIDEOXY-A-D-GLUCOPYRANOSYL-(1->4)]-2-DEOXY-, SULFATE (1:3)

CAS: 4146-30-9

Formula: C₂₃H₅₂N₆O₂₅S₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 908.8792

Ref: IN-DA00BZ3H

Framycetin sulfate

CAS: 4146-30-9

Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.

Formula: C₂₃H₅₂N₆O₂₅S₃

Purity: 99.79% - 99.89%

Color and Shape: White To Yellowish Powder

Molecular weight: 908.86

Ref: TM-T2096

Framycetin sulfate, BP, Ph. Eur. grade

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O

Purity: ≤ 3.0%

Color and Shape: White or pale yellow crystalline powder

Molecular weight: 712.72 (anhydrous)

Ref: 7W-GA7318

Framycetin sulfate

CAS: 4146-30-9

Framycetin sulfate

Purity: ≥98%

Molecular weight: 712.22g/mol

Ref: 54-BUP17823

Neomycin B Trisulfate (Framycetin Trisulfate)

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄

Color and Shape: Off-White Solid

Molecular weight: 614.65 3*98.08

Ref: 4Z-N-080009

Framycetin sulfate

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃·3H₂SO₄·xH₂O

Purity: ≥ 600IU/mg (dried basis)

Color and Shape: White to pale yellow powder

Molecular weight: 712.72 (anhydrous)

Ref: 7W-GA3510

Neomycin B Trisulfate

CAS: 4146-30-9

Formula: C₂₃H₄₆N₆O₁₃(H₂SO₄)

Molecular weight: 614.65 : 3(98.07)

Ref: ST-EA-CP-N53013

Framycetin sulphate

CAS: 119-04-0, 28002-70-2, 4146-30-9

Framycetin sulphate is a broad-spectrum antibiotic that is used to treat microbial infections. It has been shown to be effective against many gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus. Framycetin sulphate prevents bacterial growth by inhibiting protein synthesis through binding to the 30S ribosomal subunit. This binding inhibits the incorporation of amino acids into proteins, thereby preventing the production of new proteins required for cell division and growth. Framycetin sulphate also has preservative properties, which may be due to its ability to chelate metal ions such as copper and iron. Framycetin sulphate can be administered orally or topically in vivo model studies. The drug was not found to have any significant toxic effects on the liver or kidneys in vivo model studies at concentrations up to 40%.

Formula: C₂₃H₅₂N₆O₂₅S₃

Purity: Min. 95%

Molecular weight: 908.88 g/mol

Ref: 3D-FF150536