CAS 414864-00-9

N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide

Description:

N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide is a chemical compound characterized by its unique structure, which includes an N-hydroxy group and a phenylsulfamoyl moiety attached to an acrylamide backbone. This compound typically exhibits properties associated with both amides and sulfonamides, which may influence its solubility, reactivity, and potential biological activity. The presence of the N-hydroxy group suggests that it may participate in various chemical reactions, such as conjugation or oxidation, making it of interest in medicinal chemistry and drug design. Additionally, the phenylsulfamoyl group may impart specific pharmacological properties, potentially enhancing its efficacy in therapeutic applications. The compound's molecular interactions, stability, and behavior in biological systems would depend on its specific functional groups and overall molecular geometry. As with many synthetic organic compounds, safety and handling precautions should be observed, particularly in laboratory settings, due to potential toxicity or reactivity. Further studies would be necessary to fully elucidate its properties and applications in various fields, including pharmaceuticals and materials science.

Formula: C₁₅H₁₄N₂O₄S

InChI: InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)

InChI key: InChIKey=NCNRHFGMJRPRSK-UHFFFAOYSA-N

SMILES: S(NC1=CC=CC=C1)(=O)(=O)C2=CC(C=CC(NO)=O)=CC=C2

Synonyms:

• 2-Propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-
• 2-propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-, (2E)-
• Belinostat
• N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide
• N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide
• Pxd101

Belinostat (PXD101)

CAS: 414864-00-9

Formula: C₁₅H₁₄N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 318.3477

Ref: IN-DA00BZRY

Rac-Belinostat

CAS: 414864-00-9

Rac-Belinostat

Purity: ≥98%

Molecular weight: 318.35g/mol

Ref: 54-BUP13620

Rac-Belinostat

CAS: 414864-00-9

Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.

Formula: C₁₅H₁₄N₂O₄S

Purity: 99.67% - 99.96%

Color and Shape: Solid

Molecular weight: 318.35

Ref: TM-T1852

Belinostat

CAS: 414864-00-9

Belinostat is a histone deacetylase (HDAC) inhibitor, which is a synthetic compound with a targeted mechanism of action. It is derived from the hydroxamic acid class and functions by inhibiting the activity of HDAC enzymes. These enzymes are responsible for removing acetyl groups from lysine residues on histone and non-histone proteins, altering chromatin structure and affecting gene expression. By inhibiting HDACs, Belinostat leads to an accumulation of acetylated histones, promoting an open chromatin structure and reactivation of silenced genes that can suppress tumor growth.

Formula: C₁₅H₁₄N₂O₄S

Purity: Min. 95%

Molecular weight: 318.35 g/mol

Ref: 3D-PRA86400

Belinostat (PXD-101)

Controlled Product

CAS: 414864-00-9

Stability Light Sensitive
Applications Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.
References Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);

Formula: C₁₅H₁₄N₂O₄S

Color and Shape: Neat

Molecular weight: 318.35

Ref: TR-B131400