CAS 414905-09-2

Hdm2 E3 ligase inhibitor 1

CAS: 414905-09-2

Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.

Formula: C₁₀H₈F₆N₂O₃S

Molecular weight: 350.24

Ref: TM-T210014