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CAS 414910-30-8

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Casopitant mesylate

Description:
Casopitant mesylate is a chemical compound that functions primarily as a neurokinin-1 (NK1) receptor antagonist, which is significant in the treatment of conditions such as nausea and vomiting associated with chemotherapy. It is a white to off-white solid that is soluble in water and organic solvents, making it suitable for various pharmaceutical formulations. The compound is characterized by its ability to inhibit the action of substance P, a neuropeptide involved in pain perception and inflammatory processes. Casopitant mesylate has been studied for its efficacy in managing chemotherapy-induced nausea and vomiting, demonstrating a favorable safety profile in clinical trials. Its pharmacological properties are attributed to its selective binding to NK1 receptors, which are widely distributed in the central nervous system and peripheral tissues. As a mesylate salt, it enhances the stability and solubility of the active compound, facilitating its use in therapeutic applications. Overall, casopitant mesylate represents a significant advancement in supportive care for patients undergoing cancer treatment.
Formula:C31H39F7N4O5S
InChI:InChI=1/C30H35F7N4O2.CH4O3S/c1-18-13-24(31)5-6-26(18)27-17-25(40-11-9-39(10-12-40)20(3)42)7-8-41(27)28(43)38(4)19(2)21-14-22(29(32,33)34)16-23(15-21)30(35,36)37;1-5(2,3)4/h5-6,13-16,19,25,27H,7-12,17H2,1-4H3;1H3,(H,2,3,4)/t19-,25+,27-;/m1./s1
InChI key:InChIKey=YRFKYVWDPCOSTE-REWBLLDVSA-N
SMILES:C(N([C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C)(=O)N2[C@H](C[C@H](CC2)N3CCN(C(C)=O)CC3)C4=C(C)C=C(F)C=C4.S(C)(=O)(=O)O
Synonyms:
  • (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide methanesulfonate (1:1)
  • 1-Piperidinecarboxamide, 4-(4-acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-, (2R,4S)-, methanesulfonate (1:1)
  • 1-Piperidinecarboxamide, 4-(4-acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-, (2R,4S)-, monomethanesulfonate
  • 4-(S)-(4-Acetylpiperazin-1-yl)-2-(R)-(4-fluoro-2-methylphenyl)piperidine-1-carboxylic acid N-[1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]-N-methylamide methanesulfonate
  • Casopitant Mesilate
  • Casopitant mesylate
  • Gw 679769B
  • Gw-579769
  • Rezonic
  • Zunrisa
  • (2R,4S)-4-(4-Acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethyl]-2-(4-fluoro-2-Methylphenyl)-N-Methyl-
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Found 3 products.
  • Casopitant Mesylate
    TRC
    + Info

    Casopitant Mesylate

    Controlled Product
    CAS:
    Formula:C30H35F7N4O2·CH4O3S
    Color and Shape:Neat
    Molecular weight:712.719

    Ref: TR-C184800

    50mg
    10,511.00€
  • Casopitant mesylate
    Biosynth
    + Info

    Casopitant mesylate

    CAS:
    <p>Neurokinin 1 receptor (NK1R) antagonist</p>
    Formula:C31H39F7N4O5S
    Purity:Min. 95%
    Molecular weight:712.72 g/mol

    Ref: 3D-FC19832

    2mg
    491.00€
    5mg
    864.00€
  • Casopitant mesylate
    Targetmol
    + Info

    Casopitant mesylate

    CAS:
    <p>Casopitant mesylate (GW679769B): Selective, brain-permeable NK1 receptor blocker, oral antiemetic.</p>
    Formula:C31H39F7N4O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:712.72

    Ref: TM-T10688