CAS 41658-44-0

N-[(benzyloxy)carbonyl]glycyl-2-(2-amino-4-methylpentanoyl)phenylalanine - chloroacetaldehyde (1:1)

Description:

N-[(benzyloxy)carbonyl]glycyl-2-(2-amino-4-methylpentanoyl)phenylalanine - chloroacetaldehyde (1:1), with CAS number 41658-44-0, is a complex organic compound that features a combination of amino acids and a reactive aldehyde group. This substance is characterized by its structural components, which include a benzyloxycarbonyl group that serves as a protective moiety for the amino group, enhancing stability and solubility. The presence of the chloroacetaldehyde moiety indicates potential reactivity, particularly in nucleophilic addition reactions, which can be significant in synthetic organic chemistry. The compound's molecular structure suggests it may exhibit properties typical of peptides, such as potential bioactivity and interactions with biological systems. Additionally, the presence of the 2-amino-4-methylpentanoyl group may influence its steric and electronic properties, affecting its reactivity and interactions. Overall, this compound is of interest in the fields of medicinal chemistry and peptide synthesis, where it may serve as an intermediate or a building block for more complex molecules.

Formula: C₂₇H₃₄ClN₃O₇

InChI: InChI=1/C25H31N3O6.C2H3ClO/c1-16(2)12-20(26)23(30)19-11-7-6-10-18(19)13-21(24(31)32)28-22(29)14-27-25(33)34-15-17-8-4-3-5-9-17;3-1-2-4/h3-11,16,20-21H,12-15,26H2,1-2H3,(H,27,33)(H,28,29)(H,31,32);2H,1H2

SMILES: CC(C)CC(C(=O)c1ccccc1CC(C(=O)O)N=C(CN=C(O)OCc1ccccc1)O)N.C(C=O)Cl

Benzyloxycarbonylglycyl-L-leucyl-L-phenylalanine chloromethyl ketone

Controlled Product

CAS: 41658-44-0

Applications Benzyloxycarbonylglycyl-L-leucyl-L-phenylalanine chloromethyl ketone is an inhibitor of cathepsin G
References Lomas, D. A., et al.: J. Biol. Chem., 270, 23437 (1995);

Formula: C₂₆H₃₂ClN₃O₅

Color and Shape: Neat

Molecular weight: 502.002

Ref: TR-B300150

N-Benzyloxycarbonyl-Gly-Leu-Phe-CH2Cl

CAS: 41658-44-0

N-Benzyloxycarbonyl-Gly-Leu-Phe-CH2Cl is a protease inhibitor that belongs to the group of serine protease inhibitors. It inhibits soybean trypsin, a serine protease, by binding to its active site and blocking the enzyme's activity. In rat neutrophils, N-Benzyloxycarbonyl-Gly-Leu-Phe-CH2Cl inhibits the ubiquitin-proteasome pathway by binding to ubiquitin and blocking its degradation. The drug also binds to collagen and has been shown to inhibit the activation of monoclonal antibody. In skin models, N-Benzyloxycarbonyl-Gly-Leu-Phe-CH2Cl has inhibited the production of chemotactic activity in response to chloromethyl ketone, which is a specific activator of neutrophils. This drug also has an acidic pH optimum that is

Formula: C₂₆H₃₂ClN₃O₅

Purity: Min. 95%

Molecular weight: 502 g/mol

Ref: 3D-RBA65844