DHODH-IN-24, with the CAS number 418775-30-1, is a chemical compound that serves as an inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme involved in the de novo synthesis of pyrimidines. This compound is of interest in medicinal chemistry, particularly for its potential therapeutic applications in treating autoimmune diseases and certain cancers. DHODH-IN-24 is characterized by its ability to selectively inhibit the enzyme, thereby disrupting the proliferation of rapidly dividing cells that rely on pyrimidine synthesis. The compound typically exhibits a specific binding affinity to the enzyme's active site, which can be assessed through various biochemical assays. Its structural features often include functional groups that enhance solubility and bioavailability, making it suitable for further development in pharmaceutical formulations. As with many small molecule inhibitors, the efficacy and safety profile of DHODH-IN-24 would be evaluated through preclinical and clinical studies to determine its potential as a therapeutic agent.

DHODH-IN-24

418775-30-1: DHODH-IN-24, with the CAS number 418775-30-1, is a chemical compound that serves as an inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme involved in the de novo synthesis of pyrimidines. This compound is of interest in medicinal chemistry, particularly for its potential therapeutic applications in treating autoimmune diseases and certain cancers. DHODH-IN-24 is characterized by its ability to selectively inhibit the enzyme, thereby disrupting the proliferation of rapidly dividing cells that rely on pyrimidine synthesis. The compound typically exhibits a specific binding affinity to the enzyme's active site, which can be assessed through various biochemical assays. Its structural features often include functional groups that enhance solubility and bioavailability, making it suitable for further development in pharmaceutical formulations. As with many small molecule inhibitors, the efficacy and safety profile of DHODH-IN-24 would be evaluated through preclinical and clinical studies to determine its potential as a therapeutic agent.

DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].

CAS 418775-30-1

DHODH-IN-24

DHODH-IN-24

Ref: TM-T86188