CAS 4192-14-7

3′,5′-Diiodothyronine

Description:

3′,5′-Diiodothyronine, commonly referred to as diiodothyronine, is a thyroid hormone derivative that plays a significant role in regulating metabolism and physiological processes in the body. It is an iodinated phenolic compound, characterized by the presence of two iodine atoms attached to the aromatic ring of the thyronine structure. This compound is a metabolite of thyroxine (T4) and triiodothyronine (T3), and it exhibits biological activity, albeit less potent than its parent hormones. 3′,5′-Diiodothyronine is involved in various metabolic pathways, influencing energy expenditure and thermogenesis. Its chemical structure includes a phenolic hydroxyl group, contributing to its reactivity and interaction with biological receptors. The substance is typically studied in the context of thyroid function and disorders, as well as its potential therapeutic applications. Due to its specific iodine substitution pattern, it can be distinguished from other thyroid hormones, making it a subject of interest in endocrinology and metabolic research.

Formula: C₁₅H₁₃I₂NO₄

InChI: InChI=1/C15H13I2NO4/c16-11-6-10(7-12(17)14(11)19)22-9-3-1-8(2-4-9)5-13(18)15(20)21/h1-4,6-7,13,19H,5,18H2,(H,20,21)/t13-/m0/s1

InChI key: InChIKey=LROTZSUGDZPWDN-ZDUSSCGKSA-N

SMILES: O(C1=CC(I)=C(O)C(I)=C1)C2=CC=C(C[C@@H](C(O)=O)N)C=C2

Synonyms:

• O-(4-Hydroxy-3,5-diiodophenyl)-L-tyrosine
• L-Alanine, 3-[p-(4-hydroxy-3,5-diiodophenoxy)phenyl]-
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-
• Alanine, 3-[p-(4-hydroxy-3,5-diiodophenoxy)phenyl]-, L-
• 3′,5′-Diiodothyronine

3’,5’-Diiodo-L-thyronine

Controlled Product

CAS: 4192-14-7

Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.
References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)

Formula: C₁₅H₁₃I₂NO₄

Color and Shape: Neat

Molecular weight: 525.08

Ref: TR-D455156

3’,5’-Diiodo-L-thyronine

CAS: 4192-14-7

3’,5’-Diiodo-L-thyronine is a thyroid hormone analog that is used to treat hypothyroidism. It has been shown to be effective in humans with cirrhosis and women with cancer. 3’,5’-Diiodo-L-thyronine is metabolized by the liver and has a short half-life in the blood, which makes it desirable for treatment of thyroid insufficiency. This drug binds to serum proteins and may be affected by the matrix effect. The optimum pH for this drug is 7.3 and its serum levels are increased in people with high cholesterol.

Formula: C₁₅H₁₃I₂NO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 525.08 g/mol

Ref: 3D-EAA19214