CAS 41941-56-4

8-Chloro-cAMP

Description:

8-Chloro-cAMP, with the CAS number 41941-56-4, is a derivative of cyclic adenosine monophosphate (cAMP), which is a crucial second messenger in various biological processes. This compound features a chlorine atom at the 8-position of the adenine ring, which alters its biological activity compared to regular cAMP. 8-Chloro-cAMP is known for its role in research, particularly in studies related to signal transduction pathways, as it can selectively activate certain protein kinases. The presence of the chlorine atom enhances its stability and can influence its interaction with specific receptors and enzymes. In terms of solubility, it is typically soluble in water and organic solvents, making it suitable for various experimental applications. Its ability to mimic cAMP while providing distinct effects makes it a valuable tool in pharmacological and biochemical research, particularly in understanding the mechanisms of action of hormones and neurotransmitters. As with any chemical substance, proper handling and safety precautions should be observed when working with 8-Chloro-cAMP in laboratory settings.

Formula: C₁₀H₁₁ClN₅O₆P

InChI: InChI=1S/C10H11ClN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=CLLFEJLEDNXZNR-UUOKFMHZSA-N

SMILES: ClC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H]

Synonyms:

• Adenosine, 8-chloro-, cyclic 3′,5′-(hydrogen phosphate)
• 8-Chloroadenosine 3′,5′-cyclic phosphate
• 8-Chloro-cyclic AMP
• 8-Chloro-cAMP
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.

8-Chloro-cAMP

CAS: 41941-56-4

Formula: C₁₀H₁₁ClN₅O₆P

Purity: 98%

Molecular weight: 363.6510

Ref: IN-DA00BZJV

8-Chloroadenosine-cyclic-3'',5''-monophosphate dihydrate

CAS: 41941-56-4

Formula: C₁₀H₁₁ClN₅O₆P

Molecular weight: 363.65

Ref: 7W-GN4605

8-Chloro-cAMP

CAS: 41941-56-4

8-Chloro-cAMP

Purity: ≥95%

Molecular weight: 363.65g/mol

Ref: 54-OR1075505

8-Chloro-cAMP

CAS: 41941-56-4

Purity: 98%

Molecular weight: 363.6499939

Ref: 10-F615515

8-Chloroadenosine 3',5'-cyclic monophosphate dihydrate

CAS: 41941-56-4

8-Chloroadenosine 3',5'-cyclic monophosphate dihydrate (8-Cl-cAMP) is an anticancer drug that inhibits the growth of cells in vitro and in vivo. 8-Cl-cAMP is a cytostatic agent that can inhibit the proliferation of cancer cells, especially renal cell cancer cells. It also has synergistic activity with epidermal growth factor, which may be due to its ability to increase the production of reactive oxygen species and decrease mitochondrial membrane potential. 8-Cl-cAMP may have potential as an anticancer agent due to its ability to induce apoptosis and inhibit protein synthesis.

Formula: C₁₀H₁₁ClN₅O₆P·2H₂O

Purity: Min. 95%

Molecular weight: 399.69 g/mol

Ref: 3D-NC10381

8-Chloroadenosine 3',5'-cyclic monophosphate

CAS: 41941-56-4

8-Chloroadenosine 3',5'-cyclic monophosphate (8-CAM) is a potent inducer of the mitochondrial membrane potential. It has been shown to have cytotoxic effects on human myeloma cell line, HL-60 cells, and fetal bovine serum. 8-CAM has shown anticancer properties in solid tumours in mice. It was also found to be toxic to human carcinoma cell lines and synergistic with other pharmacological agents, such as doxorubicin. 8-CAM has been shown to have immunosuppressive effects in animal models and may be a potential therapeutic agent for autoimmune diseases.

Formula: C₁₀H₁₁ClN₅O₆P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 363.65 g/mol

Ref: 3D-NC10380

Tocladesine

CAS: 41941-56-4

Tocladesine, a cyclic adenosine monophosphate (cAMP) receptor agonist, is used potentially for the treatment of colorectal cancer.

Formula: C₁₀H₁₁ClN₅O₆P

Purity: 98%

Color and Shape: White To Off-White Powder

Molecular weight: 363.65

Ref: TM-T28990