CAS 4201-22-3

Tolonidine

Description:

Tolonidine, with the CAS number 4201-22-3, is a chemical compound primarily recognized for its use as an antihypertensive agent. It functions as an alpha-2 adrenergic agonist, which means it works by stimulating alpha-2 receptors in the central nervous system, leading to a decrease in sympathetic outflow and a subsequent reduction in blood pressure. The compound is typically presented as a white to off-white crystalline powder and is soluble in water and alcohol, which facilitates its formulation in various pharmaceutical preparations. Tolonidine's pharmacological effects include sedation and analgesia, making it relevant in both cardiovascular and pain management contexts. However, like many medications, it may have side effects, including sedation, dry mouth, and potential cardiovascular effects. Its use is subject to medical supervision, particularly in patients with specific health conditions. Overall, Tolonidine exemplifies the intersection of organic chemistry and pharmacology, showcasing how chemical properties can be harnessed for therapeutic purposes.

Formula: C₁₀H₁₂ClN₃

InChI: InChI=1S/C10H12ClN3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10/h2-3,6H,4-5H2,1H3,(H2,12,13,14)

InChI key: InChIKey=KWBTZIFLQYYPTH-UHFFFAOYSA-N

SMILES: N(C1=C(Cl)C=C(C)C=C1)C=2NCCN2

Synonyms:

• Tolonidinum [INN-Latin]
• 1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
• 2-(2-Chloro-4-methylanilino)-2-imidazoline
• Tolonidina
• 2-Imidazoline, 2-(2-chloro-p-toluidino)-
• Tolonidina [INN-Spanish]
• 2-(2-Chloro-p-toluidino)-2-imidazoline
• N-(2-chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
• Tolonidine
• 2-(2-Chloro-4-methylphenylamino)-2-imidazoline
• N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
• Tolonidine [INN:DCF]
• UNII-I4O795Q03O
• Tolonidinum

N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine

CAS: 4201-22-3

2-Chloro-4-methylphenyl-N-(2-chloro-4-methylphenyl)-4,5-dihydroimidazol-2amine is a potent immunosuppressive drug. It has been shown to be effective in the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. The drug has been found to be safe and effective in animal models of cardiac disease. 2C4MPI is an analog of azathioprine, which is used for the treatment of inflammatory and autoimmune diseases. In addition, this drug has been shown to have antihyperglycemic properties by inhibiting glucose production in the liver and increasing insulin sensitivity in muscle tissue. 2C4MPI also reduces collagen synthesis, which may be useful in treating inflammatory diseases that are caused by excess collagen deposition such as skin conditions like psoriasis or acne vulgaris.

Formula: C₁₀H₁₂ClN₃

Purity: Min. 95%

Molecular weight: 209.67 g/mol

Ref: 3D-EAA20122

Tolonidine

CAS: 4201-22-3

Tolonidine is orally active and has been shown to possess hypotensive. Tolonidine is a derivative of imidazoline.

Formula: C₁₀H₁₂ClN₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 209.68

Ref: TM-T17113