CAS 42074-68-0

2-Chlorotrityl chloride

Description:

2-Chlorotrityl chloride is an organic compound characterized by its chlorinated trityl structure, which features a trityl group (a phenyl group attached to a tertiary carbon) with a chlorine substituent at the 2-position. This compound is typically used as a reagent in organic synthesis, particularly in the field of medicinal chemistry and polymer chemistry. It serves as a chlorinating agent and can facilitate the introduction of various functional groups into organic molecules. The presence of the chlorine atom enhances its reactivity, making it useful for nucleophilic substitution reactions. 2-Chlorotrityl chloride is generally a solid at room temperature and is soluble in organic solvents such as dichloromethane and chloroform. Safety precautions should be taken when handling this compound, as it can be hazardous due to its reactive nature and potential toxicity. Proper storage in a cool, dry place away from light is recommended to maintain its stability.

Formula: C₁₉H₁₄Cl₂

InChI: InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H

InChI key: InChIKey=JFLSOKIMYBSASW-UHFFFAOYSA-N

SMILES: C(Cl)(C1=C(Cl)C=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• (Chloro(2-chlorophenyl)methylene)dibenzene
• 1-Chloro-2-(chlorodiphenylmethyl)Benzene
• 2-Chlorophenyldiphenylchloromethane
• 2-Chlorophenyldiphenylmethyl chloride
• 2-Chlorotrityl Chloride Resin
• 2-Chlorotrityl chloride
• Benzene, 1-chloro-2-(chlorodiphenylmethyl)-
• Chloro(2-chlorophenyl)diphenylmethane
• Diphenyl-2-chlorophenylmethyl chloride
• o-Chloro-tritylchloride
• o-Chlorotriphenylchloromethane

2-Chlorotrityl chloride on polystyrene, 1% cross-linked, 100-200 mesh, 1.0-1.4 mmol/g

CAS: 42074-68-0

2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in convergent peptide synthesis. Furthermore, it is used in the preparation of modified trityl nucleosides. In addition, it serves as a protecting group reagent for carboxylic acids forming esters. This Thermo Scient

Formula: C₁₉H₁₄Cl₂

Color and Shape: Off-white to yellow to orange, 100 to 200 mesh beads

Molecular weight: 313.22

Ref: 02-044407

(Chloro(2-chlorophenyl)methylene)dibenzene

CAS: 42074-68-0

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 313.2200012207031

Ref: 10-F237826

2-Chlorotrityl Chloride

CAS: 42074-68-0

Formula: C₁₉H₁₄Cl₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 313.2205

Ref: IN-DA00329M

Clotrimazole EP Impurity C

CAS: 42074-68-0

Formula: C₁₉H₁₄Cl₂

Color and Shape: Off-White Solid

Molecular weight: 313.22

Ref: 4Z-C-265

2-Chlorotrityl chloride

CAS: 42074-68-0

2-Chlorotrityl chloride

Purity: 98%

Molecular weight: 313.226g/mol

Ref: 54-OR1010412

2-Chlorotrityl chloride

CAS: 42074-68-0

2-Chlorotrityl chloride is an aromatic compound for biochemical experiments and drug synthesis research.

Formula: C₁₉H₁₄Cl₂

Purity: 99.36%

Molecular weight: 313.22

Ref: TM-T67607

1-Chloro-2-(chlorodiphenylmethyl)benzene

CAS: 42074-68-0

Formula: C₁₉H₁₄Cl₂

Color and Shape: Neat

Molecular weight: 313.22

Ref: 86-MM0015.03

2-Chlorotrityl Chloride

CAS: 42074-68-0

Formula: C₁₉H₁₄Cl₂

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 313.22

Ref: 3B-D2504

2-Chlorotrityl Chloride (90%)

Controlled Product

CAS: 42074-68-0

Impurity Clotrimazole EP Impurity C
Applications 2-Chlorotrityl Chloride (Clotrimazole EP Impurity C) is used in convergent peptide synthesis. 2-Chlorotrityl Chloride is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase.
References Ruda, G.F. et al.: ChemMedChem, 6, 309 (2011); Athanassopoulos, P. et al.: Tetrahed. Lett., 36, 5645 (1995);

Formula: C₁₉H₁₄Cl₂

Purity: 90%

Color and Shape: Neat

Molecular weight: 313.22

Ref: TR-C422260

Clotrimazole EP Impurity C

CAS: 42074-68-0

Formula: C₁₉H₁₄Cl₂

Molecular weight: 313.22

Ref: ST-EA-CP-C32003

2-Chlorotrityl chloride

CAS: 42074-68-0

2-Chlorotrityl chloride is a chemical compound that is synthesized by the reaction of phosphorus pentachloride and chloroform. It is a versatile building block for organic synthesis, which can be used to synthesize many different types of compounds in a single reaction. The hydroxyl group on 2-chlorotrityl chloride reacts with disulfide bonds to form thioethers, while the chlorine atom undergoes substitution reactions. 2-Chlorotrityl chloride is used in the synthesis of serine protease inhibitors and antimicrobial peptides. It also has significant cytotoxicity in biological cells, which may be due to its ability to affect cell membranes or inhibit protein synthesis.

Formula: C₁₉H₁₄Cl₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 313.22 g/mol

Ref: 3D-FC29916

2-Chlorotrityl Chloride

Controlled Product

CAS: 42074-68-0

Formula: C₁₉H₁₄Cl₂

Color and Shape: White

Molecular weight: 313.22

Ref: TR-C422261

2-Chlorotrityl chloride resin

CAS: 42074-68-0

2-Chlorotrityl chloride resin is a biological model system that is used in the study of metabolic disorders. It has been shown to have an inhibitory effect on autoimmune diseases, such as arthritis and multiple sclerosis. 2-Chlorotrityl chloride resin can also be used to treat prostate cancer cells. This polymer has a hydroxyl group, which is reactive with cyclic peptides and disulfide bonds, making it a good candidate for the synthesis of peptide hormones. The terminal residues are amides or peptides.

Formula: C₁₉H₁₄Cl₂

Purity: Min. 95%

Molecular weight: 313.22 g/mol

Ref: 3D-FC111695