CymitQuimica logo

CAS 42228-92-2

:

Acivicin

Description:
Acivicin is a chemical compound classified as a potent inhibitor of the enzyme glutamine synthetase, which plays a crucial role in nitrogen metabolism. It is a naturally occurring amino acid analog derived from microbial sources. Acivicin exhibits a unique structure that allows it to mimic glutamine, thereby interfering with its normal metabolic functions. This inhibition can lead to significant effects on cellular processes, making Acivicin of interest in cancer research and potential therapeutic applications. The compound has been studied for its ability to induce apoptosis in certain cancer cell lines, highlighting its potential as an anticancer agent. Additionally, Acivicin has shown promise in modulating immune responses, further expanding its potential applications in medicine. However, its use is limited by toxicity and side effects, necessitating careful consideration in therapeutic contexts. Overall, Acivicin represents a valuable tool in biochemical research and drug development, particularly in the fields of oncology and immunology.
Formula:C5H7ClN2O3
InChI:InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1
InChI key:InChIKey=QAWIHIJWNYOLBE-OKKQSCSOSA-N
SMILES:[C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H]
Synonyms:
  • (2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]ethanoic acid
  • (S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-isoxazoleacetic acid
  • (alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
  • (alphaS,5S)-alpha-Amino-3-chlor-4,5-dihydro-5-isoxazolylessigsaeure
  • (alphaS,5S)-alpha-Amino-3-chloro-2-isoxazoline-5-acetic acid
  • (α-S, 5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
  • (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
  • 5-Isoxazoleacetic acid, 4,5-dihydro-alpha-amino-3-chloro-, (S-(R*,R*))-
  • 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-
  • 5-Isoxazoleacetic acid, alpha-amino-3-chloro-4,5-dihydro-, (S-(R*,R*))-
  • See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 7 products.
  • Acivicin, 98+%
    Alfa Aesar By Thermo Fisher Scientific
    + Info

    Acivicin, 98+%

    CAS:
    <p>Inhibits glutamine amidotransferases in purine and pyrimidine synthetic pathways. Tumor growth inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa A</p>
    Formula:C5H7ClN2O3
    Purity:98+%
    Color and Shape:White to off-white, Powder
    Molecular weight:178.57

    Ref: 02-J63105

    10mg
    505.00€
    25mg
    To inquire
  • ACIVICIN
    Indagoo
    + Info

    ACIVICIN

    CAS:
    Formula:C5H7ClN2O3
    Purity:97%
    Color and Shape:Solid
    Molecular weight:178.5737

    Ref: IN-DA00C0CN

    10mg
    To inquire
  • CymitQuimica logo
    Apollo Scientific
    + Info

    Acivicin

    CAS:
    <p>Acivicin</p>
    Purity:98%

    Ref: 54-OR1037128

    1mg
    239.00€
    5mg
    681.00€
  • Acivicin
    Targetmol
    + Info

    Acivicin

    CAS:
    Acivicin (AT-125) is a chlorinated amino acid antibiotic produced by Streptomyces porcineus, a GGT inhibitor with anticancer and antiparasitic activity.
    Formula:C5H7ClN2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:178.57

    Ref: TM-T14114

  • Acivicin
    TRC
    + Info

    Acivicin

    Controlled Product
    CAS:
    <p>Applications Azaserine and Acivicin are classical and irreversible inhibitors of γ-Glutamyltranspeptidase (GGT). Acivicin is a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells.<br>References Hanigan, M., et al.: Biochemistry, 32, 6302 (1993); Suzuki, H., et al.: J. Bacteriol., 175, 6038 (1993); Suzuki, H., et al.: J. Biol. Chem., 277, 43536 (2002); Magdalena, L., et al.: Biochem. Pharma., 77, 76 (2009)<br></p>
    Formula:C5H7ClN2O3
    Color and Shape:Off White Solid
    Molecular weight:178.57

    Ref: TR-A190150

    1mg
    94.00€
    25mg
    1,069.00€
  • Acivicin
    Fluorochem
    + Info

    Acivicin

    CAS:
    Purity:98%
    Molecular weight:178.5700073

    Ref: 10-F791463

    10mg
    932.00€
  • (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid
    Biosynth
    + Info

    (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid

    CAS:
    <p>(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid is an inhibitor of the enzyme glutathione reductase (GR) and cytochrome P450. GR activates glutathione in cells to form a powerful antioxidant that protects against oxidative stress. (2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydroisoxazol-5-Yl]acetic acid inhibits GR and cytochrome P450 activity, leading to increased oxidative stress and neuronal death. This drug has been shown to have inhibitory properties on bowel disease by reducing the production of proinflammatory cytokines IL1β and TNFα. The compound also exhibits anti tumor response against mouse tumors by inducing apoptosis and inhibiting cell proliferation. The compound targets intracellular targets</p>
    Formula:C5H7ClN2O3
    Purity:Min. 95%
    Color and Shape:White Powder
    Molecular weight:178.57 g/mol

    Ref: 3D-FA17203

    50mg
    3,697.00€