CAS 422513-13-1

Hesperadin

Description:

Hesperadin, with the CAS number 422513-13-1, is a chemical compound that functions primarily as a selective inhibitor of the enzyme Aurora kinase. This enzyme plays a crucial role in cell division and mitosis, making Hesperadin of interest in cancer research and potential therapeutic applications. The compound is characterized by its ability to interfere with the phosphorylation of specific substrates, thereby disrupting the normal cell cycle progression. Hesperadin has been studied for its effects on various cancer cell lines, demonstrating potential in inhibiting tumor growth. Additionally, it is known for its relatively low toxicity in non-cancerous cells, which is a desirable trait for therapeutic agents. The compound is typically used in laboratory settings for research purposes, and its efficacy and safety profiles are subjects of ongoing investigation. As with many chemical substances, proper handling and safety protocols should be observed when working with Hesperadin in a laboratory environment.

Formula: C₂₉H₃₂N₄O₃S

InChI: InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-

InChI key: InChIKey=GLDSKRNGVVYJAB-DQSJHHFOSA-N

SMILES: C(\NC1=CC=C(CN2CCCCC2)C=C1)(=C\3/C=4C(NC3=O)=CC=C(NS(CC)(=O)=O)C4)/C5=CC=CC=C5

Synonyms:

• Ethanesulfonamide, N-[2,3-dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-
• Hesperadin
• N-[2,3-Dihydro-2-oxo-3-[(3Z)-phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]ethanesulfonamide
• Ethanesulfonamide, N-[(3Z)-2,3-dihydro-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indol-5-yl]-
• Hesperadine

Hesperadin

CAS: 422513-13-1

Formula: C₂₉H₃₂N₄O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 516.6544

Ref: IN-DA00C6FS

(Z)-N-[2-Oxo-3-[Phenyl[[4-(Piperidin-1-Ylmethyl)Phenyl]Amino]Methylene]Indolin-5-Yl]Ethanesulfonamide

CAS: 422513-13-1

(Z)-N-[2-Oxo-3-[Phenyl[[4-(Piperidin-1-Ylmethyl)Phenyl]Amino]Methylene]Indolin-5-Yl]Ethanesulfonamide

Purity: 98%

Molecular weight: 516.65g/mol

Ref: 54-OR1023283

Hesperadin

CAS: 422513-13-1

Hesperadin

Purity: ≥98%

Molecular weight: 516.65g/mol

Ref: 54-BUP05976

Hesperadin

CAS: 422513-13-1

Formula: C₂₉H₃₂N₄O₃S

Purity: >95.0%(HPLC)

Color and Shape: White to Yellow to Green powder to crystal

Molecular weight: 516.66

Ref: 3B-H1708

Hesperadin

CAS: 422513-13-1

Hesperadin(IC50=250 nM) effectively inhibits Aurora B.

Formula: C₂₉H₃₂N₄O₃S

Purity: 98.04% - 99.44%

Color and Shape: Solid

Molecular weight: 516.65

Ref: TM-T6532

Hesperadin

CAS: 422513-13-1

Purity: 98%

Molecular weight: 516.22

Ref: 10-F794411

Hesperadin

Controlled Product

CAS: 422513-13-1

Applications Hesperadin phosphorylates human mitotic protein complexes that control physiological changes within the cell to allow for proper and successful chromosome segregation. It also targets aurora kinases in cancer treatment, affecting the chromosomes’ regulation during mitosis.
References Hegemann, B. et al.: Sci. Sig., 4, 16 (2011); Kelly, K. et al: Curr. Drug. Targ.,

Formula: C₂₉H₃₂N₄O₃S

Color and Shape: Neat

Molecular weight: 516.65

Ref: TR-H289000

Hesperadin

CAS: 422513-13-1

Hesperadin is a natural product that has been found to have potential as a drug target for cancer and autoimmune diseases. This molecule is an inhibitor of protein synthesis, which may be due to its ability to inhibit the activity of protein kinase. Hesperadin binds to the ATP-binding site on the protein kinase and forms hydrogen bonds with amino acid residues, such as glutamine and lysine. Hesperadin also has the ability to bind actin filaments, which are important in mitotic checkpoint activation. In addition, hespedaridin has been shown to have anti-inflammatory properties in animal models. Hesperadin was originally isolated from plants belonging to the genus Prunus and is effective against glioma cells in vitro. It is also effective against infectious diseases, such as Mycobacterium tuberculosis and Streptococcus pneumoniae.

Purity: Min. 95%

Ref: 3D-FH137686