CAS 423206-00-2

Prokineticin 2 Isoform 2 (human)

CAS: 423206-00-2

Prokineticin 2 (Bv8) is one of the first neuropeptides that appears to directly convey circadian rhythm signaling to other CNS structures and, therefore, it may be a critical output molecule regulating biological rhythms. The peptide has the capacity to strongly suppress nocturnal locomotor activity. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. The peptide binds to the G-protein-coupled receptor PKR2. Gardiner et al. showed that prokineticin 2 potently inhibits food intake.

Formula: C₃₇₉H₆₀₆N₁₁₄O₁₀₁S₁₃

Purity: 96.2%

Color and Shape: White

Molecular weight: 8792.55

Ref: 01-4074529

Prokineticin 2 Isoform 2 (human) trifluoroacetate salt

CAS: 423206-00-2

Prokineticin-2 is a protein that is encoded by the PROK2 gene. It has been shown to inhibit VEGF in vitro and to be anti-inflammatory. Prokineticin-2 binds to the receptor for colony stimulating factor 1 (CSF1) and promotes angiogenesis by inducing the production of angiogenic factors such as vascular endothelial growth factor (VEGF), erythropoietin, and granulocyte macrophage colony stimulating factor (GM-CSF). It also inhibits transcriptional regulation of genes involved in inflammation, including IL-10, which inhibits IL-12 production.

Formula: C₃₇₉H₆₀₆N₁₁₄O₁₀₁S₁₃

Purity: Min. 95%

Molecular weight: 8,792.43 g/mol

Ref: 3D-FP110059