CymitQuimica logo

CAS 4238-41-9

:

Tosyllysine chloromethyl ketone hydrochloride

Description:
Tosyllysine chloromethyl ketone hydrochloride, commonly referred to as TLCK, is a synthetic compound that serves as a potent inhibitor of serine proteases. It is characterized by its structure, which includes a tosyl group, a lysine moiety, and a chloromethyl ketone functional group. TLCK is typically presented as a white to off-white crystalline powder and is soluble in water and various organic solvents, making it versatile for laboratory applications. The compound is often utilized in biochemical research to study protease activity and function, particularly in the context of enzyme inhibition. Its mechanism of action involves the formation of a covalent bond with the active site serine residue of serine proteases, effectively blocking their catalytic activity. TLCK is also noted for its stability under standard laboratory conditions, although it should be handled with care due to its reactive nature. As with many chemical substances, proper safety protocols should be followed when working with TLCK to mitigate any potential hazards.
Formula:C14H21ClN2O3S·ClH
InChI:InChI=1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H
InChI key:InChIKey=YFCUZWYIPBUQBD-UHFFFAOYSA-N
SMILES:C(NS(=O)(=O)C1=CC=C(C)C=C1)(CCCCN)C(CCl)=O.Cl
Synonyms:
  • Benzenesulfonamide, N-[5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-, hydrochloride (1:1)
  • Benzenesulfonamide, N-[5-amino-1-(chloroacetyl)pentyl]-4-methyl-, monohydrochloride
  • N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide
  • N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide hydrochloride (1:1)
  • N2-[(4-methylphenyl)sulfonyl]lysine - 1,3-dichloropropan-2-one (1:1) hydrochloride
  • Tosyllysine chloromethyl ketone hydrochloride
  • p-Toluenesulfonamide, N-[5-amino-1-(chloroacetyl)pentyl]-, hydrochloride
  • p-N-(7-Amino-1-chloro-2-oxohept-3-yl)toluenesulphonamide
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 3 products.