CAS 42399-40-6
:Deacetyldiltiazem
Description:
Deacetyldiltiazem is a chemical compound that belongs to the class of benzothiazepine derivatives, primarily known for its role as a calcium channel blocker. It is structurally related to diltiazem, which is commonly used in the treatment of hypertension and angina. Deacetyldiltiazem exhibits properties that allow it to inhibit calcium ion influx across cell membranes, thereby relaxing vascular smooth muscle and reducing cardiac workload. The compound is characterized by its moderate lipophilicity, which influences its absorption and distribution in biological systems. It typically appears as a white to off-white crystalline powder and is soluble in organic solvents but has limited solubility in water. The pharmacological effects of deacetyldiltiazem include vasodilation and a decrease in heart rate, making it useful in managing cardiovascular conditions. As with many pharmacologically active compounds, it is essential to consider its safety profile, potential side effects, and interactions with other medications when used in clinical settings.
Formula:C20H24N2O3S
InChI:InChI=1S/C20H24N2O3S/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14/h4-11,18-19,23H,12-13H2,1-3H3/t18-,19+/m1/s1
InChI key:InChIKey=NZHUXMZTSSZXSB-MOPGFXCFSA-N
SMILES:C(CN(C)C)N1C=2C(S[C@H]([C@@H](O)C1=O)C3=CC=C(OC)C=C3)=CC=CC2
Synonyms:- (2S,3S)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
- (2S,3S)-5-[2-(Dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
- 1,5-Benzothiazepin-4(5H)-one, 5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis)-
- 1,5-benzothiazepin-4(5H)-one, 5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)-
- 255-795-9
- Deacetyl-d-diltiazem
- Deacetyldiltiazem
- Desacetyldiltiazem
- (2S-cis)-5-(2-(Dimethylamino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
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Found 11 products.
(2S,3S)-5-(2-(Dimethylamino)ethyl)-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
CAS:Formula:C20H24N2O3SPurity:95%Color and Shape:SolidMolecular weight:372.4812Diltiazem EP Impurity F (Desacetyl Diltiazem)
CAS:Formula:C20H24N2O3SColor and Shape:White To Off-White SolidMolecular weight:372.48(2S,3S)-5-[2-(Dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
CAS:Controlled ProductFormula:C20H24N2O3SColor and Shape:NeatMolecular weight:372.48Desacetyl Diltiazem
CAS:<p>Impurity Diltiazem EP Impurity F<br>Applications Desacetyl Diltiazem (Diltiazem EP Impurity F) is a metabolite of Diltiazem (D460620).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),<br></p>Formula:C20H24N2O3SColor and Shape:White To BrownMolecular weight:372.48Desacetyl diltiazem
CAS:<p>Desacetyl diltiazem is a prodrug that is metabolized to the active form, diltiazem, in vivo. Desacetyl diltiazem has shown to be an inhibitor of P-glycoprotein (P-gp) and has been used for the treatment of hypertension and angina pectoris. The pharmacokinetic properties of desacetyl diltiazem have been studied in human serum, as well as in human liver and chronic oral studies. This drug has also been shown to inhibit the enzyme activities of cytochrome P450 3A4, CYP2C9, CYP2D6, and CYP3A4. Desacetyl diltiazem is not recommended for patients with hepatic impairment due to its potential for drug interactions.</p>Formula:C20H24N2O3SPurity:Min. 95%Color and Shape:Off-White To Tan SolidMolecular weight:372.48 g/molDeacetyldiltiazem
CAS:<p>Deacetyldiltiazem is a metabolite product of Diltiazem which is a coronary vasodilator, and is present in the plasma of individuals taking Diltiazem.</p>Formula:C20H25ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:408.94
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