CAS 42399-41-7

Diltiazem

Description:

Diltiazem is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It functions by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, leading to vasodilation and reduced heart rate. Diltiazem is classified as a benzothiazepine derivative and exhibits both antianginal and antihypertensive properties. The substance is typically administered in various formulations, including oral tablets and intravenous injections. Its pharmacokinetics involve extensive hepatic metabolism, and it has a relatively short half-life, necessitating multiple doses for sustained therapeutic effects. Common side effects may include dizziness, headache, and gastrointestinal disturbances. Diltiazem is contraindicated in patients with certain conditions such as severe hypotension or heart block. Overall, it plays a significant role in cardiovascular therapy, providing relief from symptoms associated with cardiac conditions while improving overall heart function.

Formula: C₂₂H₂₆N₂O₄S

InChI: InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1

InChI key: InChIKey=HSUGRBWQSSZJOP-RTWAWAEBSA-N

SMILES: O(C(C)=O)[C@@H]1[C@@H](SC=2C(N(CCN(C)C)C1=O)=CC=CC2)C3=CC=C(OC)C=C3

Synonyms:

• (+)-cis-Diltiazem
• (2S,3S)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
• 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-
• 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
• Adizem XL
• Balcor
• Cartia XT
• Coras
• Diltia XT
• Dilzem
• Dilzem retard
• d-Diltiazem
• d-cis-Diltiazem

Diltiazem

CAS: 42399-41-7

Formula: C₂₂H₂₆N₂O₄S

Purity: 99%

Color and Shape: Solid

Molecular weight: 414.5178

Ref: IN-DA01E75Y

Diltiazem

CAS: 42399-41-7

Diltiazem

Purity: ≥98%

Molecular weight: 414.52g/mol

Ref: 54-BUP16138

(+)-cis-Diltiazem Hydrochloride

CAS: 33286-22-5, 42399-41-7

Formula: C₂₂H₂₆N₂O₄S·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 450.98

Ref: 3B-D3662

Diltiazem

CAS: 42399-41-7

Diltiazem (CRD 401 free base) is an orally available L-type Ca2+ channel blocker with antihypertensive, antiarrhythmic, and cardioprotective properties that prevent post-reperfusion myocardial injury, angina pectoris, and cardiovascular-related diseases.

Formula: C₂₂H₂₆N₂O₄S

Purity: 99.51% - 99.83%

Color and Shape: White Crystalline Powder Solid

Molecular weight: 414.52

Ref: TM-T0112L

Diltiazem

Controlled Product

CAS: 42399-41-7

Applications Diltiazem is a potent vasodilator compound. Antihypertensive.
References Barrios, V. et al.: Exp. Rev. Cardiovasc. Ther., 9, 1375 (2011);

Formula: C₂₂H₂₆N₂O₄S

Color and Shape: Neat

Molecular weight: 414.52

Ref: TR-D460628