CAS 4245-41-4

Estradiol acetate

Description:

Estradiol acetate, with the CAS number 4245-41-4, is a synthetic derivative of estradiol, a natural estrogen hormone. It is characterized by its acetate ester group, which enhances its lipophilicity and stability compared to estradiol. This compound typically appears as a white to off-white crystalline powder and is soluble in organic solvents such as ethanol and chloroform, but has limited solubility in water. Estradiol acetate is primarily used in hormone replacement therapy and contraceptive formulations due to its estrogenic activity, which helps regulate various physiological processes, including the menstrual cycle and reproductive functions. Its pharmacokinetics are influenced by its esterification, allowing for prolonged action in the body compared to unmodified estradiol. Additionally, it can be administered via different routes, including intramuscular injection and transdermal patches. As with any hormone therapy, monitoring for potential side effects, such as cardiovascular risks or hormonal imbalances, is essential during its use.

Formula: C₂₀H₂₆O₃

InChI: InChI=1S/C20H26O3/c1-12(21)23-14-4-6-15-13(11-14)3-5-17-16(15)9-10-20(2)18(17)7-8-19(20)22/h4,6,11,16-19,22H,3,5,7-10H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key: InChIKey=FHXBMXJMKMWVRG-SLHNCBLASA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC(C)=O)=CC4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• (8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl acetate
• (8Xi,9Xi,14Xi,17Beta)-17-Hydroxyestra-1,3,5(10)-Trien-3-Yl Acetate
• 17β-Estradiol 3-acetate
• 17β-Hydroxy-3-acetoxyestra-1,3,5(10)-triene
• 3-Acetoxyestra-1,3,5(10)-trien-17β-ol
• 3-O-Acetylestradiol
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-acetate
• Estra-1,3,5(10)-triene-3,17β-diyl 3-acetate
• Estradiol Acetate
• Menoring
• Oestradiol-17-Beta 3-Acetate
• β-Estradiol 3-acetate

Estradiol Acetate

CAS: 4245-41-4

Formula: C₂₀H₂₆O₃

Molecular weight: 314.43

Ref: 4Z-E-0992

Estradiol Acetate

CAS: 4245-41-4

Applications Estradiol acetate is used a reactant in the preparation of a modifier conjugate through a physiologically cleavable bond for enhanced drug transport across membranes.
References Hale, R., et al.: PCT Int. Appl. (1993), WO 9325197 A1 19931223.

Formula: C₂₀H₂₆O₃

Color and Shape: Neat

Molecular weight: 314.42

Ref: TR-H454140

Estradiol Acetate-d3

Controlled Product

CAS: 4245-41-4

Applications Estradiol Acetate-d3 is the labelled version of estradiol acetate(H454140); a reactant in the preparation of a modifier conjugate through a physiologically cleavable bond for enhanced drug transport across membranes.
References Hale, R., et al.: PCT Int. Appl. (1993), WO 9325197 A1 19931223.

Formula: C₂₀D₃H₂₃O₃

Color and Shape: Neat

Molecular weight: 317.437

Ref: TR-H454142

Estradiol Acetate

CAS: 4245-41-4

Formula: C₂₀H₂₆O₃

Molecular weight: 314.4

Ref: ST-EA-CP-E3007