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CAS 42471-28-3

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Nimustine

Description:
Nimustine, also known by its chemical name, is a synthetic alkylating agent primarily used in oncology for its antitumor properties. It belongs to the class of nitrosoureas, which are known for their ability to cross the blood-brain barrier, making them particularly effective against certain types of brain tumors. The compound functions by introducing alkyl groups into DNA, leading to cross-linking and subsequent disruption of DNA replication and transcription, ultimately inducing cell death. Nimustine is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance its efficacy. Its pharmacokinetics involve rapid distribution and metabolism, with a notable half-life that can vary based on individual patient factors. Common side effects may include myelosuppression, gastrointestinal disturbances, and potential neurotoxicity, reflecting its mechanism of action and the challenges associated with treating central nervous system malignancies. As with all chemotherapeutic agents, careful monitoring and management of adverse effects are essential during treatment.
Formula:C9H13ClN6O2
InChI:InChI=1S/C9H13ClN6O2/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14)
InChI key:InChIKey=VFEDRRNHLBGPNN-UHFFFAOYSA-N
SMILES:C(NC(N(CCCl)N=O)=O)C=1C(N)=NC(C)=NC1
Synonyms:
  • 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea
  • 3-[(4-Amino-2-Methyl-Pyrimidin-5-Yl)Methyl]-1-(2-Chloroethyl)-1-Nitroso-Urea
  • 3-[(4-Amino-2-Methylpyrimidin-5-Yl)Methyl]-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride (1:1)
  • NSC 245382
  • N′-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea
  • Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-
  • Nimustine
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