CAS 42518-98-9

5-Chlorothiophene-2-carbonyl chloride

Description:

5-Chlorothiophene-2-carbonyl chloride is an organic compound characterized by its thiophene ring, which is a five-membered aromatic heterocycle containing sulfur. The presence of a chlorine atom at the 5-position and a carbonyl chloride functional group at the 2-position contributes to its reactivity and potential applications in organic synthesis. This compound is typically a colorless to pale yellow liquid or solid, depending on its purity and form. It is known for being a versatile intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. The carbonyl chloride group makes it a reactive acyl chloride, allowing it to participate in acylation reactions and form amides or esters when reacted with nucleophiles. Due to its reactivity, it should be handled with care, as it can be corrosive and may release harmful gases upon hydrolysis. Proper safety precautions, including the use of personal protective equipment, are essential when working with this compound in a laboratory setting.

Formula: C₅H₂Cl₂OS

InChI: InChI=1/C5H2Cl2OS/c6-4-2-1-3(9-4)5(7)8/h1-2H

SMILES: c1cc(Cl)sc1C(=O)Cl

Synonyms:

• 5-Chorothiophene-2-carbonyl chloride
• 2-Thiophenecarbonyl chloride, 5-chloro-

5-Chlorothiophene-2-carbonyl Chloride

CAS: 42518-98-9

Formula: C₅H₂Cl₂OS

Purity: >98.0%(GC)(T)

Color and Shape: Light orange to Yellow to Green clear liquid

Molecular weight: 181.03

Ref: 3B-C2864

5-Chlorothiophene-2-carbonyl chloride, 98%

CAS: 42518-98-9

5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or

Formula: C₅H₂Cl₂OS

Purity: 98%

Molecular weight: 181.04

Ref: 02-H61474

5-Chlorothiophene-2-carbonyl chloride

CAS: 42518-98-9

Formula: C₅H₂Cl₂OS

Purity: 97%

Color and Shape: Liquid

Molecular weight: 181.0398

Ref: IN-DA0071W9

5-Chlorothiophene-2-carbonyl chloride

CAS: 42518-98-9

5-Chlorothiophene-2-carbonyl chloride

Formula: C₅H₂Cl₂OS

Purity: 97%

Color and Shape: clear. faint yellow liquid

Molecular weight: 181.04g/mol

Ref: 54-OR200094

5-Chlorothiophene-2-carbonyl chloride

CAS: 42518-98-9

Formula: C₅H₂Cl₂OS

Purity: 95.0%

Color and Shape: Liquid

Molecular weight: 181.03

Ref: 10-F214774

Rivaroxaban Impurity 95 ( 5-Chlorothiophene-2-carbonyl Chloride)

CAS: 42518-98-9

Formula: C₅H₂Cl₂OS

Molecular weight: 179.920

Ref: 4Z-R-29108

5-Chloro-2-Thiophenecarbonyl Chloride (>90%)

Controlled Product

CAS: 42518-98-9

Stability Hygroscopic
Applications 5-Chloro-2-Thiophenecarbonyl Chloride is a reagent in the synthesis of indolinyl-thiazole based inhibitors of cellular lipid uptake. Also used in the preparation of anticoagulants and such related promising drug candidates.
References Dockendorff, C. et al.: ACS Med. Chem. Lett.., 6, 375 (2015);

Formula: C₅H₂Cl₂OS

Purity: >90%

Color and Shape: Neat

Molecular weight: 181.04

Ref: TR-C427825

5-Chlorothiophene-2-carbonyl chloride

CAS: 42518-98-9

Intermediate in the synthesis of rivaroxaban

Formula: C₅H₂Cl₂OS

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 181.04 g/mol

Ref: 3D-FC42749