CAS 42540-40-9

Cefamandole nafate

Description:

Cefamandole nafate is a semisynthetic cephalosporin antibiotic that belongs to the beta-lactam class of antibiotics. It is primarily used to treat a variety of bacterial infections, particularly those caused by Gram-positive and some Gram-negative organisms. Cefamandole nafate is characterized by its broad-spectrum antibacterial activity, which is attributed to its ability to inhibit bacterial cell wall synthesis. The compound is typically administered parenterally, as it is not well absorbed from the gastrointestinal tract. Its pharmacokinetics include a relatively short half-life, necessitating multiple doses for effective treatment. The drug is generally well-tolerated, although it may cause side effects such as allergic reactions, gastrointestinal disturbances, and alterations in liver function tests. Cefamandole nafate is also known for its potential to induce resistance in certain bacterial strains, which is a consideration in antibiotic stewardship. Overall, it is an important therapeutic option in the management of infections, particularly in a hospital setting.

Formula: C₁₉H₁₈N₆O₆S₂·Na

InChI: InChI=1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10;/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30);/t12-,14-,17-;/m1./s1

InChI key: InChIKey=FUWWBXJEMYXCMO-YCLOEFEOSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](OC=O)C3=CC=CC=C3)=O)C2=O)(SCC1CSC=4N(C)N=NN4)[H].[Na]

Synonyms:

• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-(formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, sodium salt (1:1), (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6R-[6α,7β(R*)]]-
• Bergacef
• Cedol
• Cefam
• Cefamandole Nafate
• Cefamandole formate sodium
• Cefiran
• Cemado
• Cemandil
• Cemandil sodium salt
• Cephamandole nafate
• Kefadol
• Kefandol
• Lampomandol
• Mandokef
• Mandol
• Mandolsan
• NSC 299588
• Neocefal
• O-Formylcefamandole sodium
• Pavecef
• Sodium 7-(<span class="text-smallcaps">D</span>-2-formyloxy-2-phenylacetamido)-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate
• Sodium O-formylcefamandole
• sodium (6R,7R)-7-{[(2R)-2-(formyloxy)-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• sodium (6R,7R)-7-{[(2S)-2-(formyloxy)-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• sodium (6R,7R)-7-{[(formyloxy)(phenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

CEFAMANDOLE NAFATE CRS

CAS: 42540-40-9

CEFAMANDOLE NAFATE CRS

Formula: C₁₉H₁₇N₆NaO₆S₂

Color and Shape: White. Powder.

Molecular weight: 512.4946

Ref: 41-C0682300

Sodium (6R,7R)-7-(R)-mandelamido-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate formate (ester)

CAS: 42540-40-9

Formula: C₁₉H₁₇N₆NaO₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 512.4946

Ref: IN-DA00I88D

Cefamandole nafate

CAS: 42540-40-9

Formula: C₁₉H₁₇N₆O₆S₂Na

Color and Shape: White to off-white powder

Molecular weight: 512.49

Ref: 7W-GA7688

Cefamandole nafate

CAS: 42540-40-9

Cefamandole nafate

Molecular weight: 512.49g/mol

Ref: 54-BUP15918

Cefamandole nafate

CAS: 42540-40-9

Cefamandole nafate (Cephamandole nafate) is a second-generation broad-spectrum cephalosporin antibiotic.

Formula: C₁₉H₁₇N₆NaO₆S₂

Purity: 97.47%

Color and Shape: White Solid

Molecular weight: 512.49

Ref: TM-T4992

Cefamandole Nafate

Controlled Product

CAS: 42540-40-9

Applications Antibacterial.
References Taha, M., et al.: Bioorg. Med. Chem., 16, 1218 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Formula: C₁₉H₁₇N₆O₆S₂·Na

Color and Shape: Neat

Molecular weight: 512.49

Ref: TR-C237505

Cefamandole nafate

CAS: 42540-40-9

Cefamandole nafate is an antimicrobial agent that is used for the treatment of infectious diseases. It has a broad spectrum of activity and is effective against Gram-positive and Gram-negative bacteria, such as staphylococci, streptococci, and pseudomonads. Cefamandole nafate has been shown to be active against tissue infection caused by E. coli in rats. The mechanism of action involves cell lysis and the formation of sodium carbonate. This reaction takes place when glucose is injected into the animal's intrauterine cavity before injecting cefamandole nafate solution. The chemical reaction between sodium carbonate and glucose produces water, carbon dioxide, sodium bicarbonate, and hydrogen ions. The hydrogen ions react with cefamandole to produce its active form, which then reacts with the bacterial cell wall by disrupting the cell membrane. Cefamandole nafate also inhibits protein synthesis by binding

Formula: C₁₉H₁₇N₆O₆S₂•Na

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 512.49 g/mol

Ref: 3D-FC19846

Cefamandole Nafate (DISCONTINUED)

CAS: 42540-40-9

Antibiotics nesoi

Formula: C₁₉H₁₈N₆O₆S₂·Na

Color and Shape: Crystalline Solid

Molecular weight: 513.06269

Ref: 45-1097400