CAS 42553-65-1

Crocin

Description:

Crocin is a carotenoid pigment primarily derived from the saffron plant, Crocus sativus. It is known for its vibrant yellow-orange color and is responsible for the characteristic hue of saffron. Chemically, crocin is a glycosylated derivative of crocetin, consisting of a dicarboxylic acid backbone with multiple sugar moieties attached, which enhances its solubility in water. Crocin exhibits various biological activities, including antioxidant, anti-inflammatory, and potential neuroprotective effects, making it of interest in both food and pharmaceutical industries. It is often studied for its potential therapeutic applications, particularly in the context of neurodegenerative diseases and mood disorders. Additionally, crocin is recognized for its role as a natural colorant in food products, providing a safe alternative to synthetic dyes. Its stability and bioavailability are important factors in its application, and ongoing research continues to explore its full range of health benefits and uses.

Formula: C₄₄H₆₄O₂₄

InChI: InChI=1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)28(48)24(16-46)64-42/h5-14,23-38,41-58H,15-18H2,1-4H3/b6-5+,11-7+,12-8+,19-9+,20-10+,21-13+,22-14+/t23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38-,41-,42-,43+,44+/m1/s1

InChI key: InChIKey=SEBIKDIMAPSUBY-RTJKDTQDSA-N

SMILES: C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@@H](OC(/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)\C)\C)/C)/C)=O)[C@H](O)[C@@H](O)[C@@H]2O

Synonyms:

• 6-O-β-D-glucopyranosyl-1-O-[(2E,4E,6E,8E,10Z,12E,14Z)-16-{[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]methyl}-2,6,11,15-tetramethylheptadeca-2,4,6,8,10,12,14,16-octaenoyl]-β-D-glucopyranose
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl) ester
• Crocetin bis(gentiobiosyl) ester
• Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• Crocetin di-β-gentiobiosyl ester
• Crocetin digentiobioside
• Crocin
• Crocin (gardenia fruit
• Crocin 1
• Crocin 4
• Crocin A
• Kiriyasu Oil Yellow GY
• Saffron
• Saffron (Natural)
• Trans-crocin-1
• all-trans-Crocetin di-β-<span class="text-smallcaps">D</span>-gentiobiosyl ester
• bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate (non-preferred name)
• trans-Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• α-Crocin
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranose, 6-O-β-<smallcap>D</span>-glucopyranosyl-, 1,1′-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester

Crocin (Gardenia Fruits Extract)

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Purity: multi component mixture(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 976.97

Ref: 3B-C1527

Crocin

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 976.9646

Ref: IN-DA00BXRM

Crocin

CAS: 42553-65-1

Crocin: a water-soluble carotenoid in saffron, used for flavoring, coloring, and in Chinese medicine; inhibits TNF-alpha-induced apoptosis in cells.

Formula: C₄₄H₆₄O₂₄

Purity: 98.136% - 99.27%

Color and Shape: Solid /Di-Gentiobiose Ester/ Solid

Molecular weight: 976.96

Ref: TM-T2823

Crocin

CAS: 42553-65-1

Crocin

Purity: 98%

Molecular weight: 976.97g/mol

Ref: 54-OR1026433

Crocin

CAS: 42553-65-1

Crocin

Purity: ≥98%

Molecular weight: 976.96g/mol

Ref: 54-BUP00203

Crocin I, 98%

CAS: 42553-65-1

Formula: C₄₄H₆₄O₂₄

Purity: (HPLC) ≥ 98.0%

Color and Shape: Orange to dark red powder

Molecular weight: 976.97

Ref: 7W-GY1779

Crocin I

CAS: 42553-65-1

Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.

Formula: C₄₄H₆₄O₂₄

Purity: 95%~99%

Molecular weight: 976.972

Ref: BP-BP0406

Crocin

CAS: 42553-65-1

Natural glycoside

Formula: C₄₄H₆₄O₂₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 976.98

Ref: 5G-80391

Crocin

CAS: 42553-65-1

Stability Light Sensitive
Applications Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
References Zheng, Y. Q., et al.: Brain Res., 1138, 86 (2006); Hosseinzadeh, H., et al.: PTR, 24 (5), 726 (2010); Ochiai, T., et al.: Biochim. Biophys. Acta., 1770(4), 578 (2006);

Formula: C₄₄H₆₄O₂₄

Color and Shape: Dark Yellow Crystalline Powder

Molecular weight: 976.96

Ref: TR-C794945

Crocin I

CAS: 42553-65-1

Crocin is a pharmaceutical product which is an antipyretic and analgesic medication, primarily composed of paracetamol (acetaminophen). It is synthesized through chemical processes originally derived from coal tar, although modern production predominantly utilizes petrochemical sources. The mode of action of Crocin involves the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system. This action leads to a decrease in the synthesis of prostaglandins, which are responsible for pain and fever.

Formula: C₄₄H₆₄O₂₄

Purity: Min. 98.0 Area-%

Color and Shape: Powder

Molecular weight: 976.96 g/mol

Ref: 3D-OC08286

Crocin

CAS: 42553-65-1

Purity: 95%

Molecular weight: 976.972

Ref: 10-F979316

Crocin - microscopy grade

CAS: 42553-65-1

Crocin is a carotenoid found in the fruit of Crocus sativus. It has been shown to have potential anticancer activity, as well as antioxidant and anti-inflammatory properties. Crocin has demonstrated significant cytotoxicity against cancer cells in vitro. The mechanism of action is not fully understood, but it may be due to its ability to inhibit oxidative injury and receptor activity. Crocin has also been shown to have an effect on eye disorders such as retinitis pigmentosa and macular degeneration, which may be due to its antioxidant properties. The analytical method for crocin is high performance liquid chromatography (HPLC). HPLC separation is achieved using a reversed-phase column with gradient elution using water, acetonitrile and methanol. Preparative HPLC is used for isolation from natural sources.

Formula: C₄₄H₆₄O₂₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 976.96 g/mol

Ref: 3D-FC158408