CAS 4258-85-9

(6α,11β,16α)-21-(Acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

Description:

The chemical substance known as "(6α,11β,16α)-21-(Acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione," with the CAS number 4258-85-9, is a synthetic corticosteroid. It exhibits anti-inflammatory and immunosuppressive properties, making it useful in various therapeutic applications, particularly in treating conditions such as allergies, asthma, and autoimmune disorders. The structure of this compound features a steroid backbone, characterized by a fused four-ring system, which is typical of corticosteroids. The presence of functional groups, such as the acetyloxy and hydroxy groups, contributes to its biological activity and solubility. Additionally, the halogen substitutions (chlorine and fluorine) enhance its potency and stability. This compound is often administered in a controlled manner to minimize side effects associated with corticosteroid therapy, such as adrenal suppression and metabolic disturbances. Overall, its unique structural characteristics and pharmacological properties make it a significant compound in medicinal chemistry and pharmacotherapy.

Formula: C₂₄H₃₀ClFO₅

InChI: InChI=1/C24H30ClFO5/c1-12-7-15-16-9-18(26)17-8-14(28)5-6-23(17,4)24(16,25)20(30)10-22(15,3)21(12)19(29)11-31-13(2)27/h5-6,8,12,15-16,18,20-21,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,20+,21-,22+,23+,24+/m1/s1

InChI key: InChIKey=ARPLCFGLEYFDCN-CDACMRRYSA-N

SMILES: Cl[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(COC(C)=O)=O)[C@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6α,11β,16α)-21-(Acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• 4258-85-9
• 9-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate
• Clocortolone acetate
• Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-chloro-6-fluoro-11-hydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-chloro-6α-fluoro-11β,21-dihydroxy-16α-methyl-, 21-acetate
• Sh 818
• 9-Chloro-6α-fluoro-11β-hydroxy-21-acetoxy-16α-methylpregna-1,4-diene-3,20-dione

Clocortolone Acetate

Controlled Product

CAS: 4258-85-9

Applications Clocortolone Acetate is an intermediate in the synthesis of Clocortolone (C583800), an corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
References Rehm, K. et al.: Pharmaz. Zeit., 127, 888 (1982);

Formula: C₂₄H₃₀ClFO₅

Color and Shape: Neat

Molecular weight: 452.94

Ref: TR-C583820

9-Chloro-6a-Fluoro-11b-Hydroxy-21-Acetoxy-16a-Methylpregna-1,4-Diene-3,20-Dione

Controlled Product

CAS: 4258-85-9

The drug 9-Chloro-6a-Fluoro-11b-Hydroxy-21-Acetoxy-16a-Methylpregna-1,4-Diene-3,20-Dione (CLOMID) is a polymeric matrix that is used to treat patients with choroidal neovascularization. CLOMID is delivered in an ophthalmic form and has been shown to be well tolerated. Clinical studies have shown that the drug has high values for long term efficacy and low toxicity. The drug interacts with other drugs such as warfarin and can cause severe side effects, including liver damage. CLOMID may also have a role in the treatment of inflammatory diseases such as rheumatoid arthritis and Crohn's disease due to its antiinflammatory properties.

Formula: C₂₄H₃₀ClFO₅

Purity: Min. 95%

Molecular weight: 452.94 g/mol

Ref: 3D-FC100436