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CAS 426-15-3

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21-Deoxydexamethasone

Description:
21-Deoxydexamethasone is a synthetic glucocorticoid steroid, primarily used for its anti-inflammatory and immunosuppressive properties. It is structurally related to dexamethasone but lacks a hydroxyl group at the 21 position, which influences its biological activity and potency. This compound exhibits a high affinity for the glucocorticoid receptor, leading to a range of physiological effects, including the regulation of metabolism, immune response modulation, and anti-inflammatory actions. 21-Deoxydexamethasone is often utilized in research settings to study steroid mechanisms and may have applications in treating various conditions, such as autoimmune disorders and certain types of cancer. Its pharmacokinetics include oral bioavailability and a relatively long half-life, allowing for effective dosing regimens. As with other corticosteroids, potential side effects may include metabolic changes, increased susceptibility to infections, and other systemic effects, necessitating careful monitoring during therapeutic use. Overall, 21-Deoxydexamethasone serves as an important tool in both clinical and experimental pharmacology.
Formula:C22H29FO4
InChI:InChI=1S/C22H29FO4/c1-12-9-17-16-6-5-14-10-15(25)7-8-19(14,3)21(16,23)18(26)11-20(17,4)22(12,27)13(2)24/h7-8,10,12,16-18,26-27H,5-6,9,11H2,1-4H3/t12-,16+,17+,18+,19+,20+,21+,22+/m1/s1
InChI key:InChIKey=IKGBPSZWCRRUQS-QAHQDLQKSA-N
SMILES:F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(C)=O)(O)[C@H](C)C3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]
Synonyms:
  • (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 9-Fluoro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-16α-methyl-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16α)-
  • 21-Deoxydexamethasone
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Found 4 products.