Methionine lyase, with the CAS number 42616-25-1, is an enzyme that plays a crucial role in the metabolism of sulfur-containing amino acids, particularly methionine. It catalyzes the conversion of methionine to α-ketobutyrate, ammonia, and hydrogen sulfide, a reaction that is significant in various biological processes, including the regulation of methionine levels in cells. This enzyme is typically found in certain bacteria and has garnered interest for its potential applications in cancer therapy, as it can selectively target and deplete methionine in tumor cells, which often rely on this amino acid for growth. Methionine lyase is characterized by its specificity for methionine and its ability to function in a variety of pH and temperature conditions, making it a versatile enzyme in biochemical applications. Additionally, its structure often includes a pyridoxal phosphate cofactor, which is essential for its enzymatic activity. Overall, methionine lyase is an important enzyme with implications in both fundamental biochemistry and therapeutic development.

Methionine lyase

42616-25-1: Methionine lyase, with the CAS number 42616-25-1, is an enzyme that plays a crucial role in the metabolism of sulfur-containing amino acids, particularly methionine. It catalyzes the conversion of methionine to α-ketobutyrate, ammonia, and hydrogen sulfide, a reaction that is significant in various biological processes, including the regulation of methionine levels in cells. This enzyme is typically found in certain bacteria and has garnered interest for its potential applications in cancer therapy, as it can selectively target and deplete methionine in tumor cells, which often rely on this amino acid for growth. Methionine lyase is characterized by its specificity for methionine and its ability to function in a variety of pH and temperature conditions, making it a versatile enzyme in biochemical applications. Additionally, its structure often includes a pyridoxal phosphate cofactor, which is essential for its enzymatic activity. Overall, methionine lyase is an important enzyme with implications in both fundamental biochemistry and therapeutic development.

L-Methionine γ-lyase (Methionine lyase), a multifaceted enzyme in the γ-family of pyridoxal-5’-phosphate (PLP)-dependent enzymes, catalyzes the α, γ-elimination

L-Methionine γ-lyase

<p>A pyridoxal phosphate-containing enzyme that converts L-methionine to α-ketobutyrate, ammonia and methyl mercaptan. Recombinant from e.coli source.  <br>EC 4.4.1.11</p>

CAS 42616-25-1

Methionine lyase

L-Methionine γ-lyase

Ref: TM-T79929

L-Methionine γ-lyase

Ref: 3D-EM183489