CAS 427-51-0

Cyproterone acetate

Description:

Cyproterone acetate is a synthetic steroidal anti-androgen and progestin, primarily used in the treatment of conditions such as androgen-dependent disorders, including hirsutism and acne, as well as in hormone therapy for transgender women. It functions by blocking the effects of androgens, such as testosterone, at the receptor level, and also exhibits progestational activity. The compound is characterized by its chemical formula C22H27ClO3 and a molecular weight of approximately 403.91 g/mol. Cyproterone acetate is typically administered orally and is known for its relatively high bioavailability. It is soluble in organic solvents like ethanol and chloroform but has limited solubility in water. The substance is often formulated in various dosage forms, including tablets and injectable solutions. Side effects may include weight gain, mood changes, and potential impacts on liver function, necessitating monitoring during treatment. Due to its hormonal activity, cyproterone acetate is contraindicated in certain populations, including pregnant individuals.

Formula: C₂₄H₂₉ClO₄

InChI: InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1

InChI key: InChIKey=UWFYSQMTEOIJJG-FDTZYFLXSA-N

SMILES: C[C@]12[C@@]3([C@@](C3)(C(=O)C=C1C(Cl)=C[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@]5(OC(C)=O)C(C)=O)[H])[H])[H])[H])[H]

Synonyms:

• (1R,7aR,8aS,8bS,10aS)-1-acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
• (1β,2β)-17-(Acetyloxy)-6-chloro-1,2-dihydro-3′H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate
• 1,2-alpha-Methylene-6-chloro-delta(sup 6)-17-alpha-hydroxyprogesterone acetate
• 1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate
• 1,2α-Methylene-6-chloro-17α-acetoxy-4,6-pregnadiene-3,20-dione
• 1,2α-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17α-acetate
• 1,2α-Methylene-6-chloro-Δ4,6-pregnadien-17α-ol-3,20-dione acetate
• 1,2α-Methylene-6-chloro-Δ^4,6-pregnadien-17α-ol-3,20-dione acetate
• 17-acetate de 6-chloro-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 17-acetato de 6-cloro-1-β,2-β-dihidro-17-hidroxi-3'H-ciclopropa[1,2]pregna-1,4,6-trieno-3,20-diona
• 17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione
• 17α-Acetoxy-6-chloro-1α,2α-methylenepregna-4,6-diene-3,20-dione
• 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-
• 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate
• 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1β,2β)-
• 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1β,2β-dihydro-17-hydroxy-, acetate
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1β,2β)-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1β,2β-dihydro-17-hydroxy-, acetate
• 6-Chlor-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-17-acetat
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteronacetat [German]
• 6-Chloro-1,2-alpha-methylene-17-alpha-hydroxy-delta(sup 6)-progesterone acetate
• 6-Chloro-1,2-alpha-methylene-6-dehydro-17-alpha-hydroxyprogesterone acetate
• 6-Chloro-1,2α-methylene-17α-hydroxy-Δ6-progesterone acetate
• 6-Chloro-1,2α-methylene-17α-hydroxy-Δ⁶-progesterone acetate
• 6-Chloro-1,2α-methylene-6-dehydro-17α-hydroxyprogesterone acetate
• 6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate
• 6-Chloro-17-hydroxy-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione acetate
• 6-Chloro-17-hydroxy-1α,2α-methylenepregna-4,6-diene-3,20-dione acetate
• 6-Chloro-1beta,2beta-dihydro-17-hydroxy-3'H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
• 6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate
• 6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate
• 6-chloro-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate
• Androcur
• Androcur Depot
• CPA
• Ccris 4385
• Cyclopropa[1,2]cyclopenta[a]phenanthrene, 3′H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione deriv.
• Cyprostat
• Cyproteron acetate
• Cyproteron-R acetate
• Cyproterone 17-O-acetate
• Cyproterone 17alpha-acetate
• Cyproterone 17α-acetate
• Cyproviron
• Hsdb 3592
• Nsc 81430
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1-alpha,2-alpha-methylene-, acetate
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-, acetate
• Sh 714
• Sh 80714

Cyproterone Acetate

CAS: 427-51-0

Color and Shape: Neat

Ref: 61-FOR0215.00

CYPROTERONE ACETATE CRS

CAS: 427-51-0

CYPROTERONE ACETATE CRS

Formula: C₂₄H₂₉ClO₄

Color and Shape: Added Modified

Molecular weight: 416.9377

Ref: 41-C3283000

CYPROTERONE IMPURITY MIXTURE CRS

CAS: 427-51-0

CYPROTERONE IMPURITY MIXTURE CRS

Color and Shape: Added Modified

Ref: 41-Y0001223

Cyproterone acetate

CAS: 427-51-0

Cyproterone acetate

Formula: C₂₄H₂₉ClO₄

Purity: 99.9%

Color and Shape: White

Molecular weight: 416.17544

Ref: 47-688

CYPROTERONE ACETATE FOR PEAK IDENTIFICATION CRS

CAS: 427-51-0

CYPROTERONE ACETATE FOR PEAK IDENTIFICATION CRS

Color and Shape: Added Modified

Ref: 41-Y0001390

Cyproteroneacetate

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 416.9377

Ref: IN-DA00ILMR

Cyproterone acetate

CAS: 427-51-0

Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and

Formula: C₂₄H₂₉ClO₄

Purity: 98.43% - 99.83%

Color and Shape: Crystals From Diisopropyl Ether Odour

Molecular weight: 416.94

Ref: TM-T1167

Cyproterone acetate

CAS: 427-51-0

Cyproterone acetate

Purity: ≥98%

Molecular weight: 416.94g/mol

Ref: 54-BUP16707

Cyproterone Acetate-d3

CAS: 427-51-0

Formula: C₂₄H₂₆D₃ClO₄

Color and Shape: White To Off-White Solid

Molecular weight: 419.96

Ref: 4Z-C-288

Cyproterone Acetate-d6

CAS: 427-51-0

Formula: C₂₄H₂₃D₆ClO₄

Molecular weight: 422.98

Ref: 4Z-C-285

Cyproterone Acetate

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Color and Shape: White To Off-White Solid

Molecular weight: 416.94

Ref: 4Z-C-283

Cyproterone Acetate

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 416.94

Ref: 3B-C2942

Cyproterone acetate

Controlled Product

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Color and Shape: Neat

Molecular weight: 416.94

Ref: 04-C11917100

Cyproterone Acetate

Controlled Product

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Color and Shape: Neat

Molecular weight: 416.94

Ref: 86-MM0215.00

Cyproterone Acetate-13C2-d3

CAS: 427-51-0

Formula: C₂₂₁₃C₂H₂₆D₃ClO₄

Molecular weight: 421.95

Ref: 4Z-C-284

Cyproterone acetate

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Color and Shape: White to almost white powder or crystals

Molecular weight: 416.94

Ref: 7W-GP6849

Cyproterone Acetate

Controlled Product

CAS: 427-51-0

Formula: C₂₄H₂₉ClO₄

Color and Shape: White

Molecular weight: 416.94

Ref: TR-C989100

Cyproterone acetate

Controlled Product

CAS: 427-51-0

Androgen receptor antagonist; apoptotic in hepatic cells

Formula: C₂₄H₂₉ClO₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 416.94 g/mol

Ref: 3D-FC20764

Cyproterone Acetate-d3 (Major)

Controlled Product

CAS: 427-51-0

Applications Cyproterone Acetate-d3, is the labeled analogue of Cyproterone Acetate (C989100), which combined with estrogen it is used in the treatment of acne.
References Moltz, L., et al.: Contraception, 21, 393 (1980), Hammerstein, J., et al.: J. Steroid Biochem., 29, 591 (1983)

Formula: C₂₄H₂₆D₃ClO₄

Color and Shape: Neat

Molecular weight: 419.96

Ref: TR-C989103

Cyproterone Acetate-13C2,d3 (Major)

Controlled Product

CAS: 427-51-0

Applications Labelled Cyproterone Acetate. The free alcohol is an anti-androgen; the acetate is both an anti-androgen and a progestogen. Combined with estrogen it is used in the treatment of acne.
References Moltz, L., et al.: Contraception, 21, 393 (1980), Hammerstein, J., et al.: J. Steroid Biochem., 29, 591 (1983)

Formula: C₂₂₁₃C₂H₂₆D₃ClO₄

Color and Shape: Neat

Molecular weight: 421.94

Ref: TR-C989102