CAS 4276-09-9

D-Valinol

Description:

D-Valinol, with the CAS number 4276-09-9, is an amino alcohol that belongs to the class of chiral compounds. It is characterized by its molecular structure, which includes a hydroxyl group (-OH) and an amino group (-NH2) attached to a carbon chain. D-Valinol is a colorless to pale yellow liquid with a characteristic odor and is soluble in water and organic solvents. This compound exhibits optical activity due to its chiral center, making it important in various applications, particularly in the synthesis of pharmaceuticals and agrochemicals. D-Valinol can act as a chiral auxiliary in asymmetric synthesis, facilitating the production of enantiomerically pure compounds. Additionally, it may participate in hydrogen bonding due to its hydroxyl group, influencing its reactivity and interactions with other molecules. Its properties make D-Valinol a valuable compound in both research and industrial applications, particularly in the fields of organic chemistry and medicinal chemistry.

Formula: C₅H₁₃NO

InChI: InChI=1S/C5H13NO/c1-4(2)5(6)3-7/h4-5,7H,3,6H2,1-2H3/t5-/m0/s1

InChI key: InChIKey=NWYYWIJOWOLJNR-YFKPBYRVSA-N

SMILES: [C@@H](C(C)C)(CO)N

Synonyms:

• (-)-2-Amino-3-methyl-1-butanol
• (-)-Valinol
• (2R)-2-Amino-3-methyl-1-butanol
• (2R)-2-Amino-3-methylbutan-1-ol
• (R)-(-)-2-Amino-3-methyl-1-butanol
• (R)-2-Amino-3-methylbutan-2-ol
• (R)-2-Amino-3-methylbutanol
• (R)-2-amino-3-methylbutan-1-ol
• (R)-Valinol
• 1-Butanol, 2-amino-3-methyl-, (2R)-
• 1-Butanol, 2-amino-3-methyl-, (R)-
• 1-Butanol, 2-amino-3-methyl-, <span class="text-smallcaps">D</span>-
• <span class="text-smallcaps">D</span>-Valinol
• D-valinol (R-2-amino-3-methyl-1-butanol)
• [(R)-1-(Hydroxymethyl)-2-methylpropyl]amine
• 1-Butanol, 2-amino-3-methyl-, D-
• D-Valinol
• D-VALINAL
• (R)-(-)-Z-Amino-3-Methyl-1-Butanol
• H-D-VAL-OL
• D-2-AMINO-3-METHYL-1-BUTANOL
• D-Val-ol
• 2-AMINO-3-METHYLBUTAN-1-OL
• D-(-)-VALINOL 98%

D-Valinol

CAS: 4276-09-9

Formula: C₅H₁₃NO

Purity: >98.0%(GC)(T)

Color and Shape: White or Colorless to Light yellow powder to lump to clear liquid

Molecular weight: 103.17

Ref: 3B-V0077

D-(-)-Valinol, 98%

CAS: 4276-09-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₅H₁₃NO

Purity: 98%

Color and Shape: Colorless to white to yellow, Crystals or powder or crystalline powder or fused solid or clear liquid or viscous liquid as melt

Molecular weight: 103.17

Ref: 02-L14166

D-Valinol

CAS: 4276-09-9

Formula: C₅H₁₃NO

Purity: 97%

Color and Shape: Solid

Molecular weight: 103.1628

Ref: IN-DA00I896

D-(-)-Valinol ((R)-(-)-2-Amino-3-methyl-1-butanol)

CAS: 4276-09-9

Formula: C₅H₁₃NO

Molecular weight: 103.17

Ref: 7W-GE5589

(R)-(-)-2-Amino-3-methylbutan-1-ol

CAS: 4276-09-9

(R)-(-)-2-Amino-3-methylbutan-1-ol

Formula: C₅H₁₃NO

Purity: 97%

Color and Shape: light yellow to yellow low melting solid

Molecular weight: 103.16g/mol

Ref: 54-OR5885

D-Valinol

CAS: 4276-09-9

D-Valinol is a synthetic compound that contains a chiral alcohol group. It is an ester hydrochloride salt of D-valinol and has been shown to be clinically effective in treating chronic lymphocytic leukemia (CLL). This drug is a potent inhibitor of the bcr-abl kinase, which is involved in the regulation of protein synthesis. D-Valinol binds to the kinase domain of this enzyme and inhibits its activity by preventing it from transferring phosphate groups from ATP to tyrosine residues on proteins. D-Valinol also inhibits chloride channels, which are required for cell survival.

Formula: C₅H₁₃NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 103.16 g/mol

Ref: 3D-FV36829

d-Valinol

CAS: 4276-09-9

Formula: C₅H₁₃NO

Purity: 97%

Color and Shape: Solid, Low Melting Solid

Molecular weight: 103.165

Ref: 10-F045548

D-Valinol

Controlled Product

CAS: 4276-09-9

Applications D-Valinol is used as a reagent in the synthesis of the HIV type 1 integrase inhibitor Elvitegravir (E509000). D-Valinol is also used in the preparation of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer's disease.
References Radl, S., et al.: J. Heterocyclic Chem., no vol., no pp. (2015, ahead of print); Fukunaga, K., et al.: Bioorg. Med. Chem. Lett., 25, 1086 (2015)

Formula: C₅H₁₃NO

Color and Shape: Neat

Molecular weight: 103.16

Ref: TR-V094355

D-Valinol

CAS: 4276-09-9

D-Valinol is a fine chemical that has been used as an intermediate in the synthesis of other chemicals. It is also a versatile building block for organic reactions, such as condensation reactions. D-Valinol is a white solid and has CAS No. 4276-09-9. It can be used as a reagent or catalyst in the synthesis of pharmaceuticals, agrochemicals, and other speciality chemicals. D-Valinol is also useful as an intermediate in the production of high quality research chemicals and speciality chemicals.

Formula: C₅H₁₃NO

Purity: Min. 98.0 Area-%

Molecular weight: 103.1 g/mol

Ref: 3D-Q-102724