CAS 42867-68-5

2',3'-Dideoxy-2',3'-didehydroinosine

Description:

2',3'-Dideoxy-2',3'-didehydroinosine, commonly referred to as DDI, is a synthetic nucleoside analog that exhibits antiviral properties, particularly against retroviruses such as HIV. It is characterized by the absence of hydroxyl groups at the 2' and 3' positions of the ribose sugar, which contributes to its mechanism of action as a chain terminator during viral RNA replication. The compound is typically administered in its phosphate form, which enhances its bioavailability and efficacy. DDI is known for its ability to inhibit viral reverse transcriptase, thereby preventing the conversion of viral RNA into DNA. Its chemical structure includes a purine base, specifically inosine, which is modified to enhance its antiviral activity. While DDI has been used in combination therapies for HIV treatment, it is associated with certain side effects, including potential toxicity to mitochondrial DNA. Overall, DDI represents an important class of antiretroviral agents that contribute to the management of HIV infection.

Formula: C₁₀H₁₀N₄O₃

InChI: InChI=1/C10H10N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h1-2,4-7,15H,3H2,(H,11,12,16)/t6-,7+/m0/s1

Synonyms:

• 9-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-3H-purin-6-one
• 9-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one

9-((2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-3H-purin-6(9H)-one

CAS: 42867-68-5

Formula: C₁₀H₁₀N₄O₃

Purity: %

Molecular weight: 234.2114

Ref: IN-DA00719J

Didanosine EP Impurity F

CAS: 42867-68-5

Formula: C₁₀H₁₀N₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 234.22

Ref: 4Z-D-222

2',3'-Dideoxy-2',3'-didehydroinosine

CAS: 42867-68-5

2',3'-Dideoxy-2',3'-didehydroinosine is a synthetic pyrimidine compound that has been shown to inhibit tumor growth in animal models. It is used to prepare 2',3'-dideoxy-2',3'-didehydroinosine-5'-triphosphate, which inhibits the synthesis of DNA and RNA by binding to the enzyme ribonucleotide reductase. This inhibition leads to cell death by inducing crosslinkers and inhibiting polymerase chain reaction. 2',3'-Dideoxy-2',3'-didehydroinosine can be synthesized from hydrochloric acid and carbonyl compounds such as glyoxal, acetaldehyde, or benzaldehyde.
2',3'-Dideoxy-2',3'-didehydroinosine is an important part of phylogenetic tree analysis because it provides information about evolutionary relationships between bacteria.

Formula: C₁₀H₁₀N₄O₃

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 234.21 g/mol

Ref: 3D-ND29820

Didanosine EP Impurity F

CAS: 42867-68-5

Formula: C₁₀H₁₀N₄O₃

Molecular weight: 234.21

Ref: ST-EA-CP-D114006